Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is an aggressive liver cancer primarily afflicting adolescents and young adults. Most patients with FLC harbor a heterozygous deletion on chromosome 19 that leads to the oncogenic gene fusion, DNAJB1-PRKACA. There are currently no effective therapeutics for FLC. To addr...

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Detalles Bibliográficos
Autores principales: Francisco, Adam B., Kanke, Matt, Massa, Andrew P., Dinh, Timothy A., Sritharan, Ramja, Vakili, Khashayar, Bardeesy, Nabeel, Sethupathy, Praveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220943/
https://www.ncbi.nlm.nih.gov/pubmed/35482409
http://dx.doi.org/10.1172/jci.insight.154743

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