A reengineered common chain cytokine augments CD8(+) T cell–dependent immunotherapy

Cytokine therapy is limited by undesirable off-target side effects as well as terminal differentiation and exhaustion of chronically stimulated T cells. Here, we describe the signaling properties of a potentially unique cytokine by design, where T cell surface binding and signaling are separated bet...

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Detalles Bibliográficos
Autores principales: Banerjee, Anirban, Li, Dongge, Guo, Yizhan, Mei, Zhongcheng, Lau, Christine, Chen, Kelly, Westwick, John, Klauda, Jeffery B., Schrum, Adam, Lazear, Eric R., Krupnick, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220948/
https://www.ncbi.nlm.nih.gov/pubmed/35603788
http://dx.doi.org/10.1172/jci.insight.158889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220948/
https://www.ncbi.nlm.nih.gov/pubmed/35603788
http://dx.doi.org/10.1172/jci.insight.158889

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