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A reengineered common chain cytokine augments CD8(+) T cell–dependent immunotherapy
Cytokine therapy is limited by undesirable off-target side effects as well as terminal differentiation and exhaustion of chronically stimulated T cells. Here, we describe the signaling properties of a potentially unique cytokine by design, where T cell surface binding and signaling are separated bet...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220948/ https://www.ncbi.nlm.nih.gov/pubmed/35603788 http://dx.doi.org/10.1172/jci.insight.158889 |