JAK inhibitor blocks COVID-19 cytokine–induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids

COVID-19 infection causes collapse of glomerular capillaries and loss of podocytes, culminating in a severe kidney disease called COVID-19–associated nephropathy (COVAN). The underlying mechanism of COVAN is unknown. We hypothesized that cytokines induced by COVID-19 trigger expression of pathogenic...

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Detalles Bibliográficos
Autores principales: Nystrom, Sarah E., Li, Guojie, Datta, Somenath, Soldano, Karen L., Silas, Daniel, Weins, Astrid, Hall, Gentzon, Thomas, David B., Olabisi, Opeyemi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220952/
https://www.ncbi.nlm.nih.gov/pubmed/35472001
http://dx.doi.org/10.1172/jci.insight.157432

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