IL-17–producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice

Follicular Th (Tfh) cells are key CD4(+) Th cells involved in regulating B cell differentiation in the germinal center. Mice with conditional KO (CKO) of B lymphocyte-induced maturation protein-1 (BLIMP-1) expression in CD11c(hi) DCs (Prdm1 CKO) spontaneously develop a lupus-like disease. We found a...

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Detalles Bibliográficos
Autores principales: Kim, Vera, Lee, Kyungwoo, Tian, Hong, Jang, Su Hwa, Diamond, Betty, Kim, Sun Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220957/
https://www.ncbi.nlm.nih.gov/pubmed/35674135
http://dx.doi.org/10.1172/jci.insight.157332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220957/
https://www.ncbi.nlm.nih.gov/pubmed/35674135
http://dx.doi.org/10.1172/jci.insight.157332

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