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Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection

Background: One of the main symptoms of COVID-19 is hyposmia or even anosmia. Olfactory identification is most often affected. In addition, some cognitive disorders tend to appear following the infection, particularly regarding executive functions, attention, and memory. Olfaction, and especially ol...

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Autores principales: Fiorentino, Julie, Payne, Magali, Cancian, Elisa, Plonka, Alexandra, Dumas, Louise-Émilie, Chirio, David, Demonchy, Élisa, Risso, Karine, Askenazy-Gittard, Florence, Guevara, Nicolas, Castillo, Laurent, Robert, Philippe, Manera, Valeria, Vandersteen, Clair, Gros, Auriane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221020/
https://www.ncbi.nlm.nih.gov/pubmed/35741601
http://dx.doi.org/10.3390/brainsci12060714
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author Fiorentino, Julie
Payne, Magali
Cancian, Elisa
Plonka, Alexandra
Dumas, Louise-Émilie
Chirio, David
Demonchy, Élisa
Risso, Karine
Askenazy-Gittard, Florence
Guevara, Nicolas
Castillo, Laurent
Robert, Philippe
Manera, Valeria
Vandersteen, Clair
Gros, Auriane
author_facet Fiorentino, Julie
Payne, Magali
Cancian, Elisa
Plonka, Alexandra
Dumas, Louise-Émilie
Chirio, David
Demonchy, Élisa
Risso, Karine
Askenazy-Gittard, Florence
Guevara, Nicolas
Castillo, Laurent
Robert, Philippe
Manera, Valeria
Vandersteen, Clair
Gros, Auriane
author_sort Fiorentino, Julie
collection PubMed
description Background: One of the main symptoms of COVID-19 is hyposmia or even anosmia. Olfactory identification is most often affected. In addition, some cognitive disorders tend to appear following the infection, particularly regarding executive functions, attention, and memory. Olfaction, and especially olfactory identification, is related to semantic memory which manages general knowledge about the world. The main objective of this study was to determine whether semantic memory is impaired in case of persistent post COVID-19 olfactory disorders. Methods: 84 patients (average age of 42.8 ± 13.6 years) with post COVID-19 olfactory loss were included after consulting to the ENT department. The clinical evaluation was carried out with the Pyramid and Palm Tree Test, the word-retrieval task from the Grémots, the Sniffin’ Sticks Test and the Computerised Olfactory Test for the Diagnosis of Alzheimer’s Disease. Results: Semantic memory was impaired in 20% (n = 17) of patients, especially in the 19–39 age-group. The olfactory threshold was only significantly correlated with the semantic memory scores. Conclusions: Similar to all cognitive disorders, semantic disorders can have a negative impact on quality of life if left untreated. It is essential to carry out specific assessments of post COVID-19 patients to accurately determine their disorders and to put in place the best possible rehabilitation, such as speech and language therapy, to avoid quality-of-life impairment.
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spelling pubmed-92210202022-06-24 Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection Fiorentino, Julie Payne, Magali Cancian, Elisa Plonka, Alexandra Dumas, Louise-Émilie Chirio, David Demonchy, Élisa Risso, Karine Askenazy-Gittard, Florence Guevara, Nicolas Castillo, Laurent Robert, Philippe Manera, Valeria Vandersteen, Clair Gros, Auriane Brain Sci Article Background: One of the main symptoms of COVID-19 is hyposmia or even anosmia. Olfactory identification is most often affected. In addition, some cognitive disorders tend to appear following the infection, particularly regarding executive functions, attention, and memory. Olfaction, and especially olfactory identification, is related to semantic memory which manages general knowledge about the world. The main objective of this study was to determine whether semantic memory is impaired in case of persistent post COVID-19 olfactory disorders. Methods: 84 patients (average age of 42.8 ± 13.6 years) with post COVID-19 olfactory loss were included after consulting to the ENT department. The clinical evaluation was carried out with the Pyramid and Palm Tree Test, the word-retrieval task from the Grémots, the Sniffin’ Sticks Test and the Computerised Olfactory Test for the Diagnosis of Alzheimer’s Disease. Results: Semantic memory was impaired in 20% (n = 17) of patients, especially in the 19–39 age-group. The olfactory threshold was only significantly correlated with the semantic memory scores. Conclusions: Similar to all cognitive disorders, semantic disorders can have a negative impact on quality of life if left untreated. It is essential to carry out specific assessments of post COVID-19 patients to accurately determine their disorders and to put in place the best possible rehabilitation, such as speech and language therapy, to avoid quality-of-life impairment. MDPI 2022-05-31 /pmc/articles/PMC9221020/ /pubmed/35741601 http://dx.doi.org/10.3390/brainsci12060714 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fiorentino, Julie
Payne, Magali
Cancian, Elisa
Plonka, Alexandra
Dumas, Louise-Émilie
Chirio, David
Demonchy, Élisa
Risso, Karine
Askenazy-Gittard, Florence
Guevara, Nicolas
Castillo, Laurent
Robert, Philippe
Manera, Valeria
Vandersteen, Clair
Gros, Auriane
Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
title Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
title_full Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
title_fullStr Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
title_full_unstemmed Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
title_short Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
title_sort correlations between persistent olfactory and semantic memory disorders after sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221020/
https://www.ncbi.nlm.nih.gov/pubmed/35741601
http://dx.doi.org/10.3390/brainsci12060714
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