Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis

Optic neuritis (ON), the most common ocular manifestation of multiple sclerosis, is an autoimmune inflammatory demyelinating disease also characterized by degeneration of retinal ganglion cells (RGCs) and their axons, which commonly leads to visual impairment despite attempted treatments. Although O...

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Detalles Bibliográficos
Autores principales: Ross, Ahmara G., Chaqour, Brahim, McDougald, Devin S., Dine, Kimberly E., Duong, Thu T., Shindler, Ryan E., Yue, Jipeng, Liu, Tehui, Shindler, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221096/
https://www.ncbi.nlm.nih.gov/pubmed/35740955
http://dx.doi.org/10.3390/biom12060830

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