Cargando…
Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels
Pentameric ligand-gated ion channels (pLGICs) play a leading role in synaptic communication, are implicated in a variety of neurological processes, and are important targets for the treatment of neurological and neuromuscular disorders. Endogenous lipids and lipophilic compounds are potent modulator...
Autores principales: | Ananchenko, Anna, Hussein, Toka O. K., Mody, Deepansh, Thompson, Mackenzie J., Baenziger, John E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221113/ https://www.ncbi.nlm.nih.gov/pubmed/35740939 http://dx.doi.org/10.3390/biom12060814 |
Ejemplares similares
-
Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels
por: Cheng, Wayland W. L., et al.
Publicado: (2022) -
Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
por: Slobodyanyuk, Mykhaylo, et al.
Publicado: (2022) -
Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site
por: Sridhar, Akshay, et al.
Publicado: (2021) -
Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function
por: Therien, J. P. Daniel, et al.
Publicado: (2017) -
Molecular Simulations of Hydrophobic Gating of Pentameric
Ligand Gated Ion Channels: Insights into Water and Ions
por: Rao, Shanlin, et al.
Publicado: (2021)