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Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features

Antisense oligonucleotides are a relatively new therapeutic modality and safety evaluation is still a developing area of research. We have observed that some oligonucleotides can produce acute, nonhybridization dependent, neurobehavioral side effects after intracerebroventricular (ICV) dosing in mic...

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Detalles Bibliográficos
Autores principales:	Hagedorn, Peter H., Brown, Jeffrey M., Easton, Amy, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E., Mercer, Stephen E., Li, Dong, Loy, James, Høg, Anja M., Jensen, Marianne L., Gill, Martin, Cacace, Angela M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2022
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221153/ https://www.ncbi.nlm.nih.gov/pubmed/35166597 http://dx.doi.org/10.1089/nat.2021.0071

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