Low-Dose Metronomic Topotecan and Pazopanib (TOPAZ) in Children with Relapsed or Refractory Solid Tumors: A C17 Canadian Phase I Clinical Trial

SIMPLE SUMMARY: Low-dose continuous oral chemotherapy may work together with targeted tyrosine kinase inhibitors to target a cancer’s ability to promote new blood supply (angiogenesis). We undertook a phase I study of the combination of oral topotecan and pazopanib in children with relapsed or refra...

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Detalles Bibliográficos
Autores principales: Manji, Arif, Samson, Yvan, Deyell, Rebecca J., Johnston, Donna L., Lewis, Victor A., Zorzi, Alexandra P., Berman, Jason N., Brodeur-Robb, Kathy, Morrison, Ellen, Kee, Lynn, Kumar, Sushil, Baruchel, Sylvain, Whitlock, James A., Morgenstern, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221162/
https://www.ncbi.nlm.nih.gov/pubmed/35740650
http://dx.doi.org/10.3390/cancers14122985

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