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Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging

Antisense oligonucleotides (ASOs), a novel paradigm in modern therapeutics, modulate cellular gene expression by binding to complementary messenger RNA (mRNA) sequences. While advances in ASO medicinal chemistry have greatly improved the efficiency of cellular uptake, selective uptake by specific ce...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Prabuddha, Aksamitiene, Edita, Alex, Aneesh, Shi, Jindou, Bera, Kajari, Zhang, Chi, Spillman, Darold R., Marjanovic, Marina, Fazio, Michael, Seth, Punit P., Frazier, Kendall, Hood, Steve R., Boppart, Stephen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2022
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221167/ https://www.ncbi.nlm.nih.gov/pubmed/34797690 http://dx.doi.org/10.1089/nat.2021.0059

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