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The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures

Background: Sensorimotor difficulties significantly interfere with daily activities, and when undiagnosed in early life, they may increase the risk of later life cognitive and mental health disorders. Subtests from the Luria-Nebraska Neuropsychological Battery (LNNB) discriminate sensorimotor impair...

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Autores principales: Corbo, Daniele, Placidi, Donatella, Gasparotti, Roberto, Wright, Robert, Smith, Donald R., Lucchini, Roberto G., Horton, Megan K., Colicino, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221253/
https://www.ncbi.nlm.nih.gov/pubmed/35741641
http://dx.doi.org/10.3390/brainsci12060757
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author Corbo, Daniele
Placidi, Donatella
Gasparotti, Roberto
Wright, Robert
Smith, Donald R.
Lucchini, Roberto G.
Horton, Megan K.
Colicino, Elena
author_facet Corbo, Daniele
Placidi, Donatella
Gasparotti, Roberto
Wright, Robert
Smith, Donald R.
Lucchini, Roberto G.
Horton, Megan K.
Colicino, Elena
author_sort Corbo, Daniele
collection PubMed
description Background: Sensorimotor difficulties significantly interfere with daily activities, and when undiagnosed in early life, they may increase the risk of later life cognitive and mental health disorders. Subtests from the Luria-Nebraska Neuropsychological Battery (LNNB) discriminate sensorimotor impairments predictive of sensorimotor dysfunction. However, scoring the LNNB sensorimotor assessment is highly subjective and time consuming, impeding the use of this task in epidemiologic studies. Aim: To train and validate a novel automated and image-derived scoring approach to the LNNB neuro-motor tasks for use in adolescents and young adults. Methods: We selected 46 adolescents (19.6 +/− 2.3 years, 48% male) enrolled in the prospective Public Health Impact of Metal Exposure (PHIME) study. We visually recorded the administration of five conventional sensorimotor LNNB tasks and developed automated scoring alternatives using a novel mathematical approach combining optic flow fields from recorded image sequences on a frame-by-frame basis. We then compared the conventional and image-derived LNNB task scores using Pearson’s correlations. Finally, we provided the accuracy of the novel scoring approach with Receiver Operating Characteristic (ROC) curves and the area under the ROC curves (AUC). Results: Image-derived LNNB task scores strongly correlated with conventional scores, which were assessed and confirmed by multiple administrators to limit subjectivity (Pearson’s correlation ≥ 0.70). The novel image-derived scoring approach discriminated participants with low motility (<mean population levels) with a specificity ranging from 70% to 83%, with 70% sensitivity. Conclusions: The novel image-derived LNNB task scores may contribute to the timely assessment of sensorimotor abilities and delays, and may also be effectively used in telemedicine.
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spelling pubmed-92212532022-06-24 The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures Corbo, Daniele Placidi, Donatella Gasparotti, Roberto Wright, Robert Smith, Donald R. Lucchini, Roberto G. Horton, Megan K. Colicino, Elena Brain Sci Article Background: Sensorimotor difficulties significantly interfere with daily activities, and when undiagnosed in early life, they may increase the risk of later life cognitive and mental health disorders. Subtests from the Luria-Nebraska Neuropsychological Battery (LNNB) discriminate sensorimotor impairments predictive of sensorimotor dysfunction. However, scoring the LNNB sensorimotor assessment is highly subjective and time consuming, impeding the use of this task in epidemiologic studies. Aim: To train and validate a novel automated and image-derived scoring approach to the LNNB neuro-motor tasks for use in adolescents and young adults. Methods: We selected 46 adolescents (19.6 +/− 2.3 years, 48% male) enrolled in the prospective Public Health Impact of Metal Exposure (PHIME) study. We visually recorded the administration of five conventional sensorimotor LNNB tasks and developed automated scoring alternatives using a novel mathematical approach combining optic flow fields from recorded image sequences on a frame-by-frame basis. We then compared the conventional and image-derived LNNB task scores using Pearson’s correlations. Finally, we provided the accuracy of the novel scoring approach with Receiver Operating Characteristic (ROC) curves and the area under the ROC curves (AUC). Results: Image-derived LNNB task scores strongly correlated with conventional scores, which were assessed and confirmed by multiple administrators to limit subjectivity (Pearson’s correlation ≥ 0.70). The novel image-derived scoring approach discriminated participants with low motility (<mean population levels) with a specificity ranging from 70% to 83%, with 70% sensitivity. Conclusions: The novel image-derived LNNB task scores may contribute to the timely assessment of sensorimotor abilities and delays, and may also be effectively used in telemedicine. MDPI 2022-06-08 /pmc/articles/PMC9221253/ /pubmed/35741641 http://dx.doi.org/10.3390/brainsci12060757 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corbo, Daniele
Placidi, Donatella
Gasparotti, Roberto
Wright, Robert
Smith, Donald R.
Lucchini, Roberto G.
Horton, Megan K.
Colicino, Elena
The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures
title The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures
title_full The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures
title_fullStr The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures
title_full_unstemmed The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures
title_short The Luria-Nebraska Neuropsychological Battery Neuromotor Tasks: From Conventional to Image-Derived Measures
title_sort luria-nebraska neuropsychological battery neuromotor tasks: from conventional to image-derived measures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221253/
https://www.ncbi.nlm.nih.gov/pubmed/35741641
http://dx.doi.org/10.3390/brainsci12060757
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