Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

SIMPLE SUMMARY: Changes in tumor differentiation have been observed during local recurrence in retroperitoneal sarcoma (RPS), and these changes have been reported to affect prognosis. However, the change in the tumor grade from the primary tumor to the first local recurrence, and the effect of this change on long-term outcomes, are unknown. This study reports the presence of tumor-grade changes and their effect on patient prognosis. While the grade changes did not affect the patient’s prognosis, a high grade of the primary tumor was an important factor. In addition, the risk factor for second local recurrence was a high grade of the recurrent tumor. Although this finding cannot change the treatment plan for recurrent RPS, it can provide the details of nomograms to predict the patient prognosis. ABSTRACT: In retroperitoneal sarcoma (RPS), the change in the tumor grade from the primary tumor to the first local recurrence, and the effect of this change on prognosis, are unknown. The aim of this study is to analyze whether these changes affect the prognosis of RPS. Patients who underwent surgery for a first locally recurrent RPS at Samsung Medical Center from January 2001 to February 2020 were included. The pathologic features of primary and recurrent tumors were compared, and the outcomes were measured. A total of 49 patients were investigated. There were 25 patients with different grades of primary and recurrent tumors. The improving, stable, and worsening groups contained 16 (32.7%), 24 (49%), and 9 (18.3%) patients, respectively. There was no significant difference in the prognosis between the three groups. In the analyses of the factors that affect the OS, a high grade of the primary tumor (p = 0.023) and the size of the recurrent tumor (p = 0.032) were statistically significant in both univariate and multivariate analyses. In a factor analysis of the second LR, a high-grade recurrent tumor (p = 0.032) was the only significant factor. There were tumor-grade changes between the primary tumor and recurrent tumor in RPS. However, the most important factor in prognosis is a high grade of the primary tumor.