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A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of diffe...

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Autores principales: Ji, Yuexin, Song, Wenliang, Xu, Lin, Yu, Deng-Guang, Annie Bligh, Sim Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221312/
https://www.ncbi.nlm.nih.gov/pubmed/35740919
http://dx.doi.org/10.3390/biom12060794
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author Ji, Yuexin
Song, Wenliang
Xu, Lin
Yu, Deng-Guang
Annie Bligh, Sim Wan
author_facet Ji, Yuexin
Song, Wenliang
Xu, Lin
Yu, Deng-Guang
Annie Bligh, Sim Wan
author_sort Ji, Yuexin
collection PubMed
description The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.
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spelling pubmed-92213122022-06-24 A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing Ji, Yuexin Song, Wenliang Xu, Lin Yu, Deng-Guang Annie Bligh, Sim Wan Biomolecules Review The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis. MDPI 2022-06-07 /pmc/articles/PMC9221312/ /pubmed/35740919 http://dx.doi.org/10.3390/biom12060794 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ji, Yuexin
Song, Wenliang
Xu, Lin
Yu, Deng-Guang
Annie Bligh, Sim Wan
A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing
title A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing
title_full A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing
title_fullStr A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing
title_full_unstemmed A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing
title_short A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing
title_sort review on electrospun poly(amino acid) nanofibers and their applications of hemostasis and wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221312/
https://www.ncbi.nlm.nih.gov/pubmed/35740919
http://dx.doi.org/10.3390/biom12060794
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