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A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221323/ https://www.ncbi.nlm.nih.gov/pubmed/35735555 http://dx.doi.org/10.3390/bios12060409 |
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author | Shahzad, Adil Ahmad Mushtaq, Shafaq Waris, Asim Gilani, Syed Omer Alnuwaiser, Maha Abdallah Jameel, Mohammed Khan, Niaz Bahadur |
author_facet | Shahzad, Adil Ahmad Mushtaq, Shafaq Waris, Asim Gilani, Syed Omer Alnuwaiser, Maha Abdallah Jameel, Mohammed Khan, Niaz Bahadur |
author_sort | Shahzad, Adil Ahmad |
collection | PubMed |
description | Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection of obstructive lung disease. This study was conducted on a total of 105 subjects, where 60 subjects were patients of obstructive lung disease and 45 subjects were healthy individuals. Patients were screened by means of the Pulmonary Function Test (PFT) by a pulmonologist. The gases present in the exhaled breath of all subjects were measured. The level of ammonia (32.29 ± 20.83 ppb), (68.83 ± 35.25 ppb), hydrogen sulfide (0.50 ± 0.26 ppm), (62.71 ± 22.20 ppb), and acetone (103.49 ± 35.01 ppb), (0.66 ± 0.31 ppm) in exhaled breath were significantly different (p < 0.05) between obstructive lung disease patients and healthy individuals, except alcohol, with a p-value greater than 0.05. Positive correlation was found between ammonia w.r.t Forced Expiratory Volume in 1 s (FEV1) (r = 0.74), Forced Vital Capacity (FVC) (r = 0.61) and Forced Expiratory Flow (FEF) (r = 0.63) and hydrogen sulfide w.r.t FEV1 (r = 0.54), FVC (r = 0.41) and FEF (r = 0.37). Whereas, weak correlation was found for acetone and alcohol w.r.t FEV1, FVC and PEF. Therefore, the level of ammonia and hydrogen sulfide are useful breath markers for detection of obstructive lung disease. |
format | Online Article Text |
id | pubmed-9221323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92213232022-06-24 A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease Shahzad, Adil Ahmad Mushtaq, Shafaq Waris, Asim Gilani, Syed Omer Alnuwaiser, Maha Abdallah Jameel, Mohammed Khan, Niaz Bahadur Biosensors (Basel) Article Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection of obstructive lung disease. This study was conducted on a total of 105 subjects, where 60 subjects were patients of obstructive lung disease and 45 subjects were healthy individuals. Patients were screened by means of the Pulmonary Function Test (PFT) by a pulmonologist. The gases present in the exhaled breath of all subjects were measured. The level of ammonia (32.29 ± 20.83 ppb), (68.83 ± 35.25 ppb), hydrogen sulfide (0.50 ± 0.26 ppm), (62.71 ± 22.20 ppb), and acetone (103.49 ± 35.01 ppb), (0.66 ± 0.31 ppm) in exhaled breath were significantly different (p < 0.05) between obstructive lung disease patients and healthy individuals, except alcohol, with a p-value greater than 0.05. Positive correlation was found between ammonia w.r.t Forced Expiratory Volume in 1 s (FEV1) (r = 0.74), Forced Vital Capacity (FVC) (r = 0.61) and Forced Expiratory Flow (FEF) (r = 0.63) and hydrogen sulfide w.r.t FEV1 (r = 0.54), FVC (r = 0.41) and FEF (r = 0.37). Whereas, weak correlation was found for acetone and alcohol w.r.t FEV1, FVC and PEF. Therefore, the level of ammonia and hydrogen sulfide are useful breath markers for detection of obstructive lung disease. MDPI 2022-06-13 /pmc/articles/PMC9221323/ /pubmed/35735555 http://dx.doi.org/10.3390/bios12060409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shahzad, Adil Ahmad Mushtaq, Shafaq Waris, Asim Gilani, Syed Omer Alnuwaiser, Maha Abdallah Jameel, Mohammed Khan, Niaz Bahadur A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease |
title | A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease |
title_full | A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease |
title_fullStr | A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease |
title_full_unstemmed | A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease |
title_short | A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease |
title_sort | low-cost device for measurement of exhaled breath for the detection of obstructive lung disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221323/ https://www.ncbi.nlm.nih.gov/pubmed/35735555 http://dx.doi.org/10.3390/bios12060409 |
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