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A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease

Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection...

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Autores principales: Shahzad, Adil Ahmad, Mushtaq, Shafaq, Waris, Asim, Gilani, Syed Omer, Alnuwaiser, Maha Abdallah, Jameel, Mohammed, Khan, Niaz Bahadur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221323/
https://www.ncbi.nlm.nih.gov/pubmed/35735555
http://dx.doi.org/10.3390/bios12060409
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author Shahzad, Adil Ahmad
Mushtaq, Shafaq
Waris, Asim
Gilani, Syed Omer
Alnuwaiser, Maha Abdallah
Jameel, Mohammed
Khan, Niaz Bahadur
author_facet Shahzad, Adil Ahmad
Mushtaq, Shafaq
Waris, Asim
Gilani, Syed Omer
Alnuwaiser, Maha Abdallah
Jameel, Mohammed
Khan, Niaz Bahadur
author_sort Shahzad, Adil Ahmad
collection PubMed
description Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection of obstructive lung disease. This study was conducted on a total of 105 subjects, where 60 subjects were patients of obstructive lung disease and 45 subjects were healthy individuals. Patients were screened by means of the Pulmonary Function Test (PFT) by a pulmonologist. The gases present in the exhaled breath of all subjects were measured. The level of ammonia (32.29 ± 20.83 ppb), (68.83 ± 35.25 ppb), hydrogen sulfide (0.50 ± 0.26 ppm), (62.71 ± 22.20 ppb), and acetone (103.49 ± 35.01 ppb), (0.66 ± 0.31 ppm) in exhaled breath were significantly different (p < 0.05) between obstructive lung disease patients and healthy individuals, except alcohol, with a p-value greater than 0.05. Positive correlation was found between ammonia w.r.t Forced Expiratory Volume in 1 s (FEV1) (r = 0.74), Forced Vital Capacity (FVC) (r = 0.61) and Forced Expiratory Flow (FEF) (r = 0.63) and hydrogen sulfide w.r.t FEV1 (r = 0.54), FVC (r = 0.41) and FEF (r = 0.37). Whereas, weak correlation was found for acetone and alcohol w.r.t FEV1, FVC and PEF. Therefore, the level of ammonia and hydrogen sulfide are useful breath markers for detection of obstructive lung disease.
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spelling pubmed-92213232022-06-24 A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease Shahzad, Adil Ahmad Mushtaq, Shafaq Waris, Asim Gilani, Syed Omer Alnuwaiser, Maha Abdallah Jameel, Mohammed Khan, Niaz Bahadur Biosensors (Basel) Article Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection of obstructive lung disease. This study was conducted on a total of 105 subjects, where 60 subjects were patients of obstructive lung disease and 45 subjects were healthy individuals. Patients were screened by means of the Pulmonary Function Test (PFT) by a pulmonologist. The gases present in the exhaled breath of all subjects were measured. The level of ammonia (32.29 ± 20.83 ppb), (68.83 ± 35.25 ppb), hydrogen sulfide (0.50 ± 0.26 ppm), (62.71 ± 22.20 ppb), and acetone (103.49 ± 35.01 ppb), (0.66 ± 0.31 ppm) in exhaled breath were significantly different (p < 0.05) between obstructive lung disease patients and healthy individuals, except alcohol, with a p-value greater than 0.05. Positive correlation was found between ammonia w.r.t Forced Expiratory Volume in 1 s (FEV1) (r = 0.74), Forced Vital Capacity (FVC) (r = 0.61) and Forced Expiratory Flow (FEF) (r = 0.63) and hydrogen sulfide w.r.t FEV1 (r = 0.54), FVC (r = 0.41) and FEF (r = 0.37). Whereas, weak correlation was found for acetone and alcohol w.r.t FEV1, FVC and PEF. Therefore, the level of ammonia and hydrogen sulfide are useful breath markers for detection of obstructive lung disease. MDPI 2022-06-13 /pmc/articles/PMC9221323/ /pubmed/35735555 http://dx.doi.org/10.3390/bios12060409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shahzad, Adil Ahmad
Mushtaq, Shafaq
Waris, Asim
Gilani, Syed Omer
Alnuwaiser, Maha Abdallah
Jameel, Mohammed
Khan, Niaz Bahadur
A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
title A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
title_full A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
title_fullStr A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
title_full_unstemmed A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
title_short A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
title_sort low-cost device for measurement of exhaled breath for the detection of obstructive lung disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221323/
https://www.ncbi.nlm.nih.gov/pubmed/35735555
http://dx.doi.org/10.3390/bios12060409
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