Differential HIF2α Protein Expression in Human Carotid Body and Adrenal Medulla under Physiologic and Tumorigenic Conditions

SIMPLE SUMMARY: Thoraco-abdominal paraganglioma and pheochromocytoma (PPGL) are pathogenically linked to mutations in SDH genes. Loss-of-function of SDH has been associated with stabilization of HIF2α, which otherwise would be degraded via oxygen-sensitive mechanisms. SDH dysfunction also predispose...

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Detalles Bibliográficos
Autores principales: Celada, Lucía, Cubiella, Tamara, San-Juan-Guardado, Jaime, San José Martínez, Andrés, Valdés, Nuria, Jiménez-Fonseca, Paula, Díaz, Ignacio, Enguita, Jose María, Astudillo, Aurora, Álvarez-González, Enol, Sierra, Luisa María, Chiara, María-Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221385/
https://www.ncbi.nlm.nih.gov/pubmed/35740651
http://dx.doi.org/10.3390/cancers14122986

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