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Serum autoantibodyome reveals that healthy individuals share common autoantibodies.

Autoantibodies are a hallmark of both autoimmune disease and cancer, but they also occur in healthy individuals. Here, we perform a meta-analysis of nine datasets and focus on the common autoantibodies shared by healthy individuals. We report 77 common autoantibodies based on the protein microarray...

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Autores principales: Shome, Mahasish, Chung, Yunro, Chavan, Ramani, Park, Jin G., Qiu, Ji, LaBaer, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221390/
https://www.ncbi.nlm.nih.gov/pubmed/35649350
http://dx.doi.org/10.1016/j.celrep.2022.110873
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author Shome, Mahasish
Chung, Yunro
Chavan, Ramani
Park, Jin G.
Qiu, Ji
LaBaer, Joshua
author_facet Shome, Mahasish
Chung, Yunro
Chavan, Ramani
Park, Jin G.
Qiu, Ji
LaBaer, Joshua
author_sort Shome, Mahasish
collection PubMed
description Autoantibodies are a hallmark of both autoimmune disease and cancer, but they also occur in healthy individuals. Here, we perform a meta-analysis of nine datasets and focus on the common autoantibodies shared by healthy individuals. We report 77 common autoantibodies based on the protein microarray data obtained from probing 182 healthy individual sera on 7,653 human proteins and an additional 90 healthy individual sera on 1,666 human proteins. There is no gender bias; however, the number of autoantibodies increase with age, plateauing around adolescence. We use a bioinformatics pipeline to determine possible molecular-mimicry peptides that can contribute to the elicitation of these common autoantibodies. There is enrichment of intrinsic properties of proteins like hydrophilicity, basicity, aromaticity, and flexibility for common autoantigens. Subcellular localization and tissue-expression analysis reveal that several common autoantigens are sequestered from the circulating autoantibodies.
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spelling pubmed-92213902022-06-23 Serum autoantibodyome reveals that healthy individuals share common autoantibodies. Shome, Mahasish Chung, Yunro Chavan, Ramani Park, Jin G. Qiu, Ji LaBaer, Joshua Cell Rep Article Autoantibodies are a hallmark of both autoimmune disease and cancer, but they also occur in healthy individuals. Here, we perform a meta-analysis of nine datasets and focus on the common autoantibodies shared by healthy individuals. We report 77 common autoantibodies based on the protein microarray data obtained from probing 182 healthy individual sera on 7,653 human proteins and an additional 90 healthy individual sera on 1,666 human proteins. There is no gender bias; however, the number of autoantibodies increase with age, plateauing around adolescence. We use a bioinformatics pipeline to determine possible molecular-mimicry peptides that can contribute to the elicitation of these common autoantibodies. There is enrichment of intrinsic properties of proteins like hydrophilicity, basicity, aromaticity, and flexibility for common autoantigens. Subcellular localization and tissue-expression analysis reveal that several common autoantigens are sequestered from the circulating autoantibodies. 2022-05-31 /pmc/articles/PMC9221390/ /pubmed/35649350 http://dx.doi.org/10.1016/j.celrep.2022.110873 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Shome, Mahasish
Chung, Yunro
Chavan, Ramani
Park, Jin G.
Qiu, Ji
LaBaer, Joshua
Serum autoantibodyome reveals that healthy individuals share common autoantibodies.
title Serum autoantibodyome reveals that healthy individuals share common autoantibodies.
title_full Serum autoantibodyome reveals that healthy individuals share common autoantibodies.
title_fullStr Serum autoantibodyome reveals that healthy individuals share common autoantibodies.
title_full_unstemmed Serum autoantibodyome reveals that healthy individuals share common autoantibodies.
title_short Serum autoantibodyome reveals that healthy individuals share common autoantibodies.
title_sort serum autoantibodyome reveals that healthy individuals share common autoantibodies.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221390/
https://www.ncbi.nlm.nih.gov/pubmed/35649350
http://dx.doi.org/10.1016/j.celrep.2022.110873
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