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The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy

Worldwide, the prevalence of surgery under general anesthesia has significantly increased, both because of modern anesthetic and pain-control techniques and because of better diagnosis and the increased complexity of surgical techniques. Apart from developing new concepts in the surgical field, rese...

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Autores principales: Ritiu, Stelian Adrian, Rogobete, Alexandru Florin, Sandesc, Dorel, Bedreag, Ovidiu Horea, Papurica, Marius, Popovici, Sonia Elena, Toma, Daiana, Ivascu, Robert Iulian, Velovan, Raluca, Garofil, Dragos Nicolae, Corneci, Dan, Bratu, Lavinia Melania, Pahontu, Elena Mihaela, Pistol, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221536/
https://www.ncbi.nlm.nih.gov/pubmed/35741011
http://dx.doi.org/10.3390/cells11121880
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author Ritiu, Stelian Adrian
Rogobete, Alexandru Florin
Sandesc, Dorel
Bedreag, Ovidiu Horea
Papurica, Marius
Popovici, Sonia Elena
Toma, Daiana
Ivascu, Robert Iulian
Velovan, Raluca
Garofil, Dragos Nicolae
Corneci, Dan
Bratu, Lavinia Melania
Pahontu, Elena Mihaela
Pistol, Adriana
author_facet Ritiu, Stelian Adrian
Rogobete, Alexandru Florin
Sandesc, Dorel
Bedreag, Ovidiu Horea
Papurica, Marius
Popovici, Sonia Elena
Toma, Daiana
Ivascu, Robert Iulian
Velovan, Raluca
Garofil, Dragos Nicolae
Corneci, Dan
Bratu, Lavinia Melania
Pahontu, Elena Mihaela
Pistol, Adriana
author_sort Ritiu, Stelian Adrian
collection PubMed
description Worldwide, the prevalence of surgery under general anesthesia has significantly increased, both because of modern anesthetic and pain-control techniques and because of better diagnosis and the increased complexity of surgical techniques. Apart from developing new concepts in the surgical field, researchers and clinicians are now working on minimizing the impact of surgical trauma and offering minimal invasive procedures due to the recent discoveries in the field of cellular and molecular mechanisms that have revealed a systemic inflammatory and pro-oxidative impact not only in the perioperative period but also in the long term, contributing to more difficult recovery, increased morbidity and mortality, and a negative financial impact. Detailed molecular and cellular analysis has shown an overproduction of inflammatory and pro-oxidative species, responsible for augmenting the systemic inflammatory status and making postoperative recovery more difficult. Moreover, there are a series of changes in certain epigenetic structures, the most important being the microRNAs. This review describes the most important molecular and cellular mechanisms that impact the surgical patient undergoing general anesthesia, and it presents a series of antioxidant therapies that can reduce systemic inflammation.
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spelling pubmed-92215362022-06-24 The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy Ritiu, Stelian Adrian Rogobete, Alexandru Florin Sandesc, Dorel Bedreag, Ovidiu Horea Papurica, Marius Popovici, Sonia Elena Toma, Daiana Ivascu, Robert Iulian Velovan, Raluca Garofil, Dragos Nicolae Corneci, Dan Bratu, Lavinia Melania Pahontu, Elena Mihaela Pistol, Adriana Cells Review Worldwide, the prevalence of surgery under general anesthesia has significantly increased, both because of modern anesthetic and pain-control techniques and because of better diagnosis and the increased complexity of surgical techniques. Apart from developing new concepts in the surgical field, researchers and clinicians are now working on minimizing the impact of surgical trauma and offering minimal invasive procedures due to the recent discoveries in the field of cellular and molecular mechanisms that have revealed a systemic inflammatory and pro-oxidative impact not only in the perioperative period but also in the long term, contributing to more difficult recovery, increased morbidity and mortality, and a negative financial impact. Detailed molecular and cellular analysis has shown an overproduction of inflammatory and pro-oxidative species, responsible for augmenting the systemic inflammatory status and making postoperative recovery more difficult. Moreover, there are a series of changes in certain epigenetic structures, the most important being the microRNAs. This review describes the most important molecular and cellular mechanisms that impact the surgical patient undergoing general anesthesia, and it presents a series of antioxidant therapies that can reduce systemic inflammation. MDPI 2022-06-09 /pmc/articles/PMC9221536/ /pubmed/35741011 http://dx.doi.org/10.3390/cells11121880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ritiu, Stelian Adrian
Rogobete, Alexandru Florin
Sandesc, Dorel
Bedreag, Ovidiu Horea
Papurica, Marius
Popovici, Sonia Elena
Toma, Daiana
Ivascu, Robert Iulian
Velovan, Raluca
Garofil, Dragos Nicolae
Corneci, Dan
Bratu, Lavinia Melania
Pahontu, Elena Mihaela
Pistol, Adriana
The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy
title The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy
title_full The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy
title_fullStr The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy
title_full_unstemmed The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy
title_short The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy
title_sort impact of general anesthesia on redox stability and epigenetic inflammation pathways: crosstalk on perioperative antioxidant therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221536/
https://www.ncbi.nlm.nih.gov/pubmed/35741011
http://dx.doi.org/10.3390/cells11121880
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