Cargando…

Role of Seipin in Human Diseases and Experimental Animal Models

Seipin, a protein encoded by the Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene, is famous for its key role in the biogenesis of lipid droplets and type 2 congenital generalised lipodystrophy (CGL2). BSCL2 gene mutations result in genetic diseases including CGL2, progressive encephal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yuying, Yang, Xinmin, Peng, Linrui, Xia, Qing, Zhang, Yuwei, Huang, Wei, Liu, Tingting, Jia, Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221541/ https://www.ncbi.nlm.nih.gov/pubmed/35740965 http://dx.doi.org/10.3390/biom12060840

Ejemplares similares

Seipin—still a mysterious protein?
por: Salo, Veijo T.
Publicado: (2023)

Exploring Seipin: From Biochemistry to Bioinformatics Predictions
por: Craveiro Sarmento, Aquiles Sales, et al.
Publicado: (2018)

Promethin Is a Conserved Seipin Partner Protein
por: Castro, Inês G., et al.
Publicado: (2019)

Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease
por: Magré, Jocelyne, et al.
Publicado: (2022)

Towards a mechanistic understanding of lipodystrophy and seipin functions
por: Wee, Kenneth, et al.
Publicado: (2014)

Seipin is required for converting nascent to mature lipid droplets
por: Wang, Huajin, et al.
Publicado: (2016)

Seipin negatively regulates sphingolipid production at the ER–LD contact site
por: Su, Wei-Cheng, et al.
Publicado: (2019)

Suppression of Adipogenesis by Pathogenic Seipin Mutant Is Associated with Inflammatory Response
por: Qiu, Wenjie, et al.
Publicado: (2013)

Seipin regulates ER–lipid droplet contacts and cargo delivery
por: Salo, Veijo T, et al.
Publicado: (2016)

Retinyl esters form lipid droplets independently of triacylglycerol and seipin
por: Molenaar, Martijn R., et al.
Publicado: (2021)

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
por: Payne, Victoria A., et al.
Publicado: (2008)

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
por: Fei, Weihua, et al.
Publicado: (2008)

Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation
por: Tian, Yuan, et al.
Publicado: (2011)

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin
por: Sui, Xuewu, et al.
Publicado: (2018)

Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
por: Bai, Bo, et al.
Publicado: (2019)

Seipin regulates the formation of nuclear lipid droplets from a distance
por: Du, Ximing, et al.
Publicado: (2020)

LDIP cooperates with SEIPIN and LDAP to facilitate lipid droplet biogenesis in Arabidopsis
por: Pyc, Michal, et al.
Publicado: (2021)

Seipin forms a flexible cage at lipid droplet formation sites
por: Arlt, Henning, et al.
Publicado: (2022)

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane
por: Prasanna, Xavier, et al.
Publicado: (2021)

Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p
por: Han, Sungwon, et al.
Publicado: (2015)

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms
por: Sim, M. F. Michelle, et al.
Publicado: (2013)

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation
por: Eisenberg-Bord, Michal, et al.
Publicado: (2018)

Wrapping up the fats—a structure of the lipid droplet biogenesis protein seipin
por: Bohnert, Maria
Publicado: (2018)

SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis
por: Jin, Yi, et al.
Publicado: (2020)

Deletion of Seipin Attenuates Vascular Function and the Anticontractile Effect of Perivascular Adipose Tissue
por: Wang, Mengyu, et al.
Publicado: (2021)

Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity
por: McGrath, Cody, et al.
Publicado: (2022)

Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice
por: Wu, Xiaoyue, et al.
Publicado: (2021)

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology
por: Cartwright, Bethany R., et al.
Publicado: (2015)

Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility
por: El Zowalaty, A E, et al.
Publicado: (2015)

Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner
por: Sołtysik, Kamil, et al.
Publicado: (2020)

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
por: Klug, Yoel A., et al.
Publicado: (2021)

Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters
por: Renne, Mike F., et al.
Publicado: (2022)

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research
por: Yang, Xinmin, et al.
Publicado: (2020)

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites
por: Grippa, Alexandra, et al.
Publicado: (2015)

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum
por: Wang, Sihui, et al.
Publicado: (2018)

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis
por: Choudhary, Vineet, et al.
Publicado: (2020)

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain
por: Cao, Zhe, et al.
Publicado: (2019)

Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy
por: Mcilroy, George D., et al.
Publicado: (2020)

Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane
por: Kim, Siyoung, et al.
Publicado: (2022)

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase
por: Pagac, Martin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vhrupmulbdpkf84tgbe9h25def