New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants

In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, KA-104, that was previously discovered by our group. Consequently, a series of 22 original compounds has been designe...

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Detalles Bibliográficos
Autores principales: Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Andres-Mach, Marta, Szewczyk, Aleksandra, Latacz, Gniewomir, Szulczyk, Bartłomiej, Socała, Katarzyna, Nieoczym, Dorota, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Kamiński, Rafał M., Kamiński, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221546/
https://www.ncbi.nlm.nih.gov/pubmed/35740990
http://dx.doi.org/10.3390/cells11121862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221546/
https://www.ncbi.nlm.nih.gov/pubmed/35740990
http://dx.doi.org/10.3390/cells11121862

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