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Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review

Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic...

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Autores principales: Shahnam, Adel, Sayer, Robyn, Herbst, Unine, Sharma, Raghwa, Yoon, Won-hee, Dinihan, Tim, Gao, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221652/
https://www.ncbi.nlm.nih.gov/pubmed/35735440
http://dx.doi.org/10.3390/curroncol29060331
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author Shahnam, Adel
Sayer, Robyn
Herbst, Unine
Sharma, Raghwa
Yoon, Won-hee
Dinihan, Tim
Gao, Bo
author_facet Shahnam, Adel
Sayer, Robyn
Herbst, Unine
Sharma, Raghwa
Yoon, Won-hee
Dinihan, Tim
Gao, Bo
author_sort Shahnam, Adel
collection PubMed
description Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic malignancy. We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. In addition to low FDG uptake observed in these peritoneal masses, a PET scan showed hypermetabolic lymphadenopathy and pulmonary and spleen lesions suggesting widespread metastases. Subsequent surgical resection confirmed a mixed pathology with GTS and sarcoidosis. We reviewed the current literature evidence of GTS and sarcoidosis as a benign cause of lymphadenopathy in cancer patients. We emphasize the importance of a tissue diagnosis before instituting therapy for presumed cancer recurrence to avoid potentially fatal diagnostic traps and management errors. A multiple disciplinary team approach is imperative in managing patients with suspected recurrent immature teratomas.
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spelling pubmed-92216522022-06-24 Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review Shahnam, Adel Sayer, Robyn Herbst, Unine Sharma, Raghwa Yoon, Won-hee Dinihan, Tim Gao, Bo Curr Oncol Case Report Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic malignancy. We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. In addition to low FDG uptake observed in these peritoneal masses, a PET scan showed hypermetabolic lymphadenopathy and pulmonary and spleen lesions suggesting widespread metastases. Subsequent surgical resection confirmed a mixed pathology with GTS and sarcoidosis. We reviewed the current literature evidence of GTS and sarcoidosis as a benign cause of lymphadenopathy in cancer patients. We emphasize the importance of a tissue diagnosis before instituting therapy for presumed cancer recurrence to avoid potentially fatal diagnostic traps and management errors. A multiple disciplinary team approach is imperative in managing patients with suspected recurrent immature teratomas. MDPI 2022-06-07 /pmc/articles/PMC9221652/ /pubmed/35735440 http://dx.doi.org/10.3390/curroncol29060331 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Shahnam, Adel
Sayer, Robyn
Herbst, Unine
Sharma, Raghwa
Yoon, Won-hee
Dinihan, Tim
Gao, Bo
Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
title Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
title_full Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
title_fullStr Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
title_full_unstemmed Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
title_short Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
title_sort growing teratoma syndrome in the setting of sarcoidosis: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221652/
https://www.ncbi.nlm.nih.gov/pubmed/35735440
http://dx.doi.org/10.3390/curroncol29060331
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