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Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review
Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221652/ https://www.ncbi.nlm.nih.gov/pubmed/35735440 http://dx.doi.org/10.3390/curroncol29060331 |
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author | Shahnam, Adel Sayer, Robyn Herbst, Unine Sharma, Raghwa Yoon, Won-hee Dinihan, Tim Gao, Bo |
author_facet | Shahnam, Adel Sayer, Robyn Herbst, Unine Sharma, Raghwa Yoon, Won-hee Dinihan, Tim Gao, Bo |
author_sort | Shahnam, Adel |
collection | PubMed |
description | Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic malignancy. We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. In addition to low FDG uptake observed in these peritoneal masses, a PET scan showed hypermetabolic lymphadenopathy and pulmonary and spleen lesions suggesting widespread metastases. Subsequent surgical resection confirmed a mixed pathology with GTS and sarcoidosis. We reviewed the current literature evidence of GTS and sarcoidosis as a benign cause of lymphadenopathy in cancer patients. We emphasize the importance of a tissue diagnosis before instituting therapy for presumed cancer recurrence to avoid potentially fatal diagnostic traps and management errors. A multiple disciplinary team approach is imperative in managing patients with suspected recurrent immature teratomas. |
format | Online Article Text |
id | pubmed-9221652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92216522022-06-24 Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review Shahnam, Adel Sayer, Robyn Herbst, Unine Sharma, Raghwa Yoon, Won-hee Dinihan, Tim Gao, Bo Curr Oncol Case Report Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic malignancy. We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. In addition to low FDG uptake observed in these peritoneal masses, a PET scan showed hypermetabolic lymphadenopathy and pulmonary and spleen lesions suggesting widespread metastases. Subsequent surgical resection confirmed a mixed pathology with GTS and sarcoidosis. We reviewed the current literature evidence of GTS and sarcoidosis as a benign cause of lymphadenopathy in cancer patients. We emphasize the importance of a tissue diagnosis before instituting therapy for presumed cancer recurrence to avoid potentially fatal diagnostic traps and management errors. A multiple disciplinary team approach is imperative in managing patients with suspected recurrent immature teratomas. MDPI 2022-06-07 /pmc/articles/PMC9221652/ /pubmed/35735440 http://dx.doi.org/10.3390/curroncol29060331 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Shahnam, Adel Sayer, Robyn Herbst, Unine Sharma, Raghwa Yoon, Won-hee Dinihan, Tim Gao, Bo Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review |
title | Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review |
title_full | Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review |
title_fullStr | Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review |
title_full_unstemmed | Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review |
title_short | Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review |
title_sort | growing teratoma syndrome in the setting of sarcoidosis: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221652/ https://www.ncbi.nlm.nih.gov/pubmed/35735440 http://dx.doi.org/10.3390/curroncol29060331 |
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