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Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study

There are growing concerns that some COVID-19 survivors may acquire fibrosis and other irreversible lung abnormalities. The purpose of this prospective study was to assess the rate and predictors of complete resolution of COVID-19 pneumonia by pursuing a hypothetical relation between time and imagin...

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Autores principales: Manolescu, Diana, Timar, Bogdan, Bratosin, Felix, Rosca, Ovidiu, Citu, Cosmin, Oancea, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221666/
https://www.ncbi.nlm.nih.gov/pubmed/35741206
http://dx.doi.org/10.3390/diagnostics12061397
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author Manolescu, Diana
Timar, Bogdan
Bratosin, Felix
Rosca, Ovidiu
Citu, Cosmin
Oancea, Cristian
author_facet Manolescu, Diana
Timar, Bogdan
Bratosin, Felix
Rosca, Ovidiu
Citu, Cosmin
Oancea, Cristian
author_sort Manolescu, Diana
collection PubMed
description There are growing concerns that some COVID-19 survivors may acquire fibrosis and other irreversible lung abnormalities. The purpose of this prospective study was to assess the rate and predictors of complete resolution of COVID-19 pneumonia by pursuing a hypothetical relation between time and imaging pattern evolution using HRCT findings. A monocentric prospective cohort study with a consecutive-case enrolment design was implemented during a five-month period, having a total of 683 post-COVID patients eligible for inclusion and 635 evaluations with complete follow-up for chest HRCT. The target for post-COVID evaluations consisted of performing HRCT 90 days after a confirmed SARS-CoV-2 infection. The studied patients had an average age of 54 years, ranging between 18 and 85 years old, and an average duration from the first symptoms until HRCT was performed of 74 days. At the post-COVID follow-up, 25.8% had a complete imagistic remission. The most common appearance with HRCT was “ground glass” in 86.6% in patients with persistent COVID-19, followed by reticulations, present in 78.8%, and respectively pleural thickening in 41.2% of cases. The mean total HRCT scores were statistically significantly higher in patients older than 65 years (10.6 ± 6.0) compared to the 40–65 group (6.1 ± 6.1) and the 18–40 age group (2.7 ± 4.8) (p < 0.001). Chest HRCT is a “time window” in documenting temporal persistent radiologic features of lung injury 90 days after SARS-CoV-2 infection, determining the pathologic basis of so-called “long COVID”. The complete remission was associated with a significantly higher average follow-up period and a significantly lower average patient age. Persistent HRCT features of ground glass, reticulation, and pleural thickening are associated with a higher total CT score and older age.
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spelling pubmed-92216662022-06-24 Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study Manolescu, Diana Timar, Bogdan Bratosin, Felix Rosca, Ovidiu Citu, Cosmin Oancea, Cristian Diagnostics (Basel) Article There are growing concerns that some COVID-19 survivors may acquire fibrosis and other irreversible lung abnormalities. The purpose of this prospective study was to assess the rate and predictors of complete resolution of COVID-19 pneumonia by pursuing a hypothetical relation between time and imaging pattern evolution using HRCT findings. A monocentric prospective cohort study with a consecutive-case enrolment design was implemented during a five-month period, having a total of 683 post-COVID patients eligible for inclusion and 635 evaluations with complete follow-up for chest HRCT. The target for post-COVID evaluations consisted of performing HRCT 90 days after a confirmed SARS-CoV-2 infection. The studied patients had an average age of 54 years, ranging between 18 and 85 years old, and an average duration from the first symptoms until HRCT was performed of 74 days. At the post-COVID follow-up, 25.8% had a complete imagistic remission. The most common appearance with HRCT was “ground glass” in 86.6% in patients with persistent COVID-19, followed by reticulations, present in 78.8%, and respectively pleural thickening in 41.2% of cases. The mean total HRCT scores were statistically significantly higher in patients older than 65 years (10.6 ± 6.0) compared to the 40–65 group (6.1 ± 6.1) and the 18–40 age group (2.7 ± 4.8) (p < 0.001). Chest HRCT is a “time window” in documenting temporal persistent radiologic features of lung injury 90 days after SARS-CoV-2 infection, determining the pathologic basis of so-called “long COVID”. The complete remission was associated with a significantly higher average follow-up period and a significantly lower average patient age. Persistent HRCT features of ground glass, reticulation, and pleural thickening are associated with a higher total CT score and older age. MDPI 2022-06-05 /pmc/articles/PMC9221666/ /pubmed/35741206 http://dx.doi.org/10.3390/diagnostics12061397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manolescu, Diana
Timar, Bogdan
Bratosin, Felix
Rosca, Ovidiu
Citu, Cosmin
Oancea, Cristian
Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study
title Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study
title_full Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study
title_fullStr Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study
title_full_unstemmed Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study
title_short Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study
title_sort predictors for covid-19 complete remission with hrct pattern evolution: a monocentric, prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221666/
https://www.ncbi.nlm.nih.gov/pubmed/35741206
http://dx.doi.org/10.3390/diagnostics12061397
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