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SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix

Numerous studies have demonstrated that SARS-CoV-2 can be inactivated by ultraviolet (UV) radiation. However, there are few data available on the relative efficacy of different wavelengths of UV radiation and visible light, which complicates assessments of UV decontamination interventions. The prese...

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Autores principales: Schuit, Michael A., Larason, Thomas C., Krause, Melissa L., Green, Brian M., Holland, Brian P., Wood, Stewart P., Grantham, Steven, Zong, Yuqin, Zarobila, Clarence J., Freeburger, Denise L., Miller, David M., Bohannon, Jordan K., Ratnesar-Shumate, Shanna A., Blatchley, Ernest R., Li, Xing, Dabisch, Paul A., Miller, C. Cameron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221687/
https://www.ncbi.nlm.nih.gov/pubmed/35779426
http://dx.doi.org/10.1016/j.jphotobiol.2022.112503
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author Schuit, Michael A.
Larason, Thomas C.
Krause, Melissa L.
Green, Brian M.
Holland, Brian P.
Wood, Stewart P.
Grantham, Steven
Zong, Yuqin
Zarobila, Clarence J.
Freeburger, Denise L.
Miller, David M.
Bohannon, Jordan K.
Ratnesar-Shumate, Shanna A.
Blatchley, Ernest R.
Li, Xing
Dabisch, Paul A.
Miller, C. Cameron
author_facet Schuit, Michael A.
Larason, Thomas C.
Krause, Melissa L.
Green, Brian M.
Holland, Brian P.
Wood, Stewart P.
Grantham, Steven
Zong, Yuqin
Zarobila, Clarence J.
Freeburger, Denise L.
Miller, David M.
Bohannon, Jordan K.
Ratnesar-Shumate, Shanna A.
Blatchley, Ernest R.
Li, Xing
Dabisch, Paul A.
Miller, C. Cameron
author_sort Schuit, Michael A.
collection PubMed
description Numerous studies have demonstrated that SARS-CoV-2 can be inactivated by ultraviolet (UV) radiation. However, there are few data available on the relative efficacy of different wavelengths of UV radiation and visible light, which complicates assessments of UV decontamination interventions. The present study evaluated the effects of monochromatic radiation at 16 wavelengths from 222 nm through 488 nm on SARS-CoV-2 in liquid aliquots and dried droplets of water and simulated saliva. The data were used to generate a set of action spectra which quantify the susceptibility of SARS-CoV-2 to genome damage and inactivation across the tested wavelengths. UVC wavelengths (≤280 nm) were most effective for inactivating SARS-CoV-2, although inactivation rates were dependent on sample type. Results from this study suggest that UV radiation can effectively inactivate SARS-CoV-2 in liquids and dried droplets, and provide a foundation for understanding the factors which affect the efficacy of different wavelengths in real-world settings.
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spelling pubmed-92216872022-06-24 SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix Schuit, Michael A. Larason, Thomas C. Krause, Melissa L. Green, Brian M. Holland, Brian P. Wood, Stewart P. Grantham, Steven Zong, Yuqin Zarobila, Clarence J. Freeburger, Denise L. Miller, David M. Bohannon, Jordan K. Ratnesar-Shumate, Shanna A. Blatchley, Ernest R. Li, Xing Dabisch, Paul A. Miller, C. Cameron J Photochem Photobiol B Article Numerous studies have demonstrated that SARS-CoV-2 can be inactivated by ultraviolet (UV) radiation. However, there are few data available on the relative efficacy of different wavelengths of UV radiation and visible light, which complicates assessments of UV decontamination interventions. The present study evaluated the effects of monochromatic radiation at 16 wavelengths from 222 nm through 488 nm on SARS-CoV-2 in liquid aliquots and dried droplets of water and simulated saliva. The data were used to generate a set of action spectra which quantify the susceptibility of SARS-CoV-2 to genome damage and inactivation across the tested wavelengths. UVC wavelengths (≤280 nm) were most effective for inactivating SARS-CoV-2, although inactivation rates were dependent on sample type. Results from this study suggest that UV radiation can effectively inactivate SARS-CoV-2 in liquids and dried droplets, and provide a foundation for understanding the factors which affect the efficacy of different wavelengths in real-world settings. The Authors. Published by Elsevier B.V. 2022-08 2022-06-23 /pmc/articles/PMC9221687/ /pubmed/35779426 http://dx.doi.org/10.1016/j.jphotobiol.2022.112503 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schuit, Michael A.
Larason, Thomas C.
Krause, Melissa L.
Green, Brian M.
Holland, Brian P.
Wood, Stewart P.
Grantham, Steven
Zong, Yuqin
Zarobila, Clarence J.
Freeburger, Denise L.
Miller, David M.
Bohannon, Jordan K.
Ratnesar-Shumate, Shanna A.
Blatchley, Ernest R.
Li, Xing
Dabisch, Paul A.
Miller, C. Cameron
SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
title SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
title_full SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
title_fullStr SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
title_full_unstemmed SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
title_short SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
title_sort sars-cov-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221687/
https://www.ncbi.nlm.nih.gov/pubmed/35779426
http://dx.doi.org/10.1016/j.jphotobiol.2022.112503
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