Cargando…
Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals
Parathyroid hormone-related peptide (PTHrP) is expressed at a wide range of sites in the body and performs different functions including vasodilation, relaxation of smooth muscle cells, and regulation of bone development. PTHrP also mediates hypercalcemia related to neoplastic diseases. However, ref...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221726/ https://www.ncbi.nlm.nih.gov/pubmed/35740833 http://dx.doi.org/10.3390/children9060896 |
_version_ | 1784732693571829760 |
---|---|
author | Brescia, Vincenzo Fontana, Antonietta Lovero, Roberto Capobianco, Carmela Marsico, Stella Vita De Chirico, Tiziana Pinto, Carla Mascolo, Elisa Cazzolla, Angela Pia Faienza, Maria Felicia Di Serio, Francesca |
author_facet | Brescia, Vincenzo Fontana, Antonietta Lovero, Roberto Capobianco, Carmela Marsico, Stella Vita De Chirico, Tiziana Pinto, Carla Mascolo, Elisa Cazzolla, Angela Pia Faienza, Maria Felicia Di Serio, Francesca |
author_sort | Brescia, Vincenzo |
collection | PubMed |
description | Parathyroid hormone-related peptide (PTHrP) is expressed at a wide range of sites in the body and performs different functions including vasodilation, relaxation of smooth muscle cells, and regulation of bone development. PTHrP also mediates hypercalcemia related to neoplastic diseases. However, reference ranges specific method and age were not evaluated. We establish PTHrP reference ranges in apparently healthy, normocalcemic, normophosphatemic pediatric individuals. In this observational prospective, study we measured PTHrP in serum from 178 samples (55.06% male 44.94% female) from apparently healthy pediatric subjects [median age 10 years (range 1–18)] subunit ELISA method The statistical analysis performed provided for the calculation of the 95% reference interval, right-sided, with a non-parametric percentile method (CLSI C28-A3). Upper reference limits (URL) for PTHrP was 2.89 ng/mL (2.60 to 3.18; 90% CI). No significant differences were found between the median PTHrP concentrations in males vs females and in the age range categories selected. Comprehensive normal values for PTHrP are indispensable to the assessment of calcium phosphorus dysfunction in children. Severe hypercalcemia is a rare, but clinically significant condition, in infancy and childhood. PTHrP values higher than the reference value may help to distinguish the hypercalcemic product of a malignancy, paraneoplastic syndromes mediated by PTHrP, from other causes. |
format | Online Article Text |
id | pubmed-9221726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92217262022-06-24 Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals Brescia, Vincenzo Fontana, Antonietta Lovero, Roberto Capobianco, Carmela Marsico, Stella Vita De Chirico, Tiziana Pinto, Carla Mascolo, Elisa Cazzolla, Angela Pia Faienza, Maria Felicia Di Serio, Francesca Children (Basel) Article Parathyroid hormone-related peptide (PTHrP) is expressed at a wide range of sites in the body and performs different functions including vasodilation, relaxation of smooth muscle cells, and regulation of bone development. PTHrP also mediates hypercalcemia related to neoplastic diseases. However, reference ranges specific method and age were not evaluated. We establish PTHrP reference ranges in apparently healthy, normocalcemic, normophosphatemic pediatric individuals. In this observational prospective, study we measured PTHrP in serum from 178 samples (55.06% male 44.94% female) from apparently healthy pediatric subjects [median age 10 years (range 1–18)] subunit ELISA method The statistical analysis performed provided for the calculation of the 95% reference interval, right-sided, with a non-parametric percentile method (CLSI C28-A3). Upper reference limits (URL) for PTHrP was 2.89 ng/mL (2.60 to 3.18; 90% CI). No significant differences were found between the median PTHrP concentrations in males vs females and in the age range categories selected. Comprehensive normal values for PTHrP are indispensable to the assessment of calcium phosphorus dysfunction in children. Severe hypercalcemia is a rare, but clinically significant condition, in infancy and childhood. PTHrP values higher than the reference value may help to distinguish the hypercalcemic product of a malignancy, paraneoplastic syndromes mediated by PTHrP, from other causes. MDPI 2022-06-15 /pmc/articles/PMC9221726/ /pubmed/35740833 http://dx.doi.org/10.3390/children9060896 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Brescia, Vincenzo Fontana, Antonietta Lovero, Roberto Capobianco, Carmela Marsico, Stella Vita De Chirico, Tiziana Pinto, Carla Mascolo, Elisa Cazzolla, Angela Pia Faienza, Maria Felicia Di Serio, Francesca Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals |
title | Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals |
title_full | Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals |
title_fullStr | Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals |
title_full_unstemmed | Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals |
title_short | Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals |
title_sort | parathyroid hormone-related peptide (pthrp): evaluation of pediatric, covariate-stratified reference intervals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221726/ https://www.ncbi.nlm.nih.gov/pubmed/35740833 http://dx.doi.org/10.3390/children9060896 |
work_keys_str_mv | AT bresciavincenzo parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT fontanaantonietta parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT loveroroberto parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT capobiancocarmela parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT marsicostellavita parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT dechiricotiziana parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT pintocarla parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT mascoloelisa parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT cazzollaangelapia parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT faienzamariafelicia parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals AT diseriofrancesca parathyroidhormonerelatedpeptidepthrpevaluationofpediatriccovariatestratifiedreferenceintervals |