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Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review

Previous studies suggest that the most common cause of spontaneous intracerebral hemorrhage in children and adolescents is arteriovenous malformations (AVMs). However, an update containing recently published data on pediatric spontaneous intracranial hemorrhages is lacking. The aim of this study is...

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Autores principales: Ciochon, Urszula Maria, Bindslev, Julie Bolette Brix, Hoei-Hansen, Christina Engel, Truelsen, Thomas Clement, Larsen, Vibeke Andrée, Nielsen, Michael Bachmann, Hansen, Adam Espe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221737/
https://www.ncbi.nlm.nih.gov/pubmed/35741269
http://dx.doi.org/10.3390/diagnostics12061459
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author Ciochon, Urszula Maria
Bindslev, Julie Bolette Brix
Hoei-Hansen, Christina Engel
Truelsen, Thomas Clement
Larsen, Vibeke Andrée
Nielsen, Michael Bachmann
Hansen, Adam Espe
author_facet Ciochon, Urszula Maria
Bindslev, Julie Bolette Brix
Hoei-Hansen, Christina Engel
Truelsen, Thomas Clement
Larsen, Vibeke Andrée
Nielsen, Michael Bachmann
Hansen, Adam Espe
author_sort Ciochon, Urszula Maria
collection PubMed
description Previous studies suggest that the most common cause of spontaneous intracerebral hemorrhage in children and adolescents is arteriovenous malformations (AVMs). However, an update containing recently published data on pediatric spontaneous intracranial hemorrhages is lacking. The aim of this study is to systematically analyze the published data on the etiologies and risk factors of pediatric spontaneous intracranial hemorrhage. This systematic review was performed in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A search in PubMed, Embase, Scopus, Web of Science and Cochrane Library was conducted aiming for articles published in year 2000 and later, containing data on etiology and risk factors of spontaneous intracranial hemorrhages in unselected cohorts of patients aged between 1 month and 18 years. As a result, forty studies were eligible for data extraction and final analysis. These included 7931 children and adolescents with 4009 reported etiologies and risk factors. A marked variety of reported etiologies and risk factors among studies was observed. Vascular etiologies were the most frequently reported cause of pediatric spontaneous intracranial hemorrhages (n = 1727, 43.08% of all identified etiologies or risk factors), with AVMs being the most common vascular cause (n = 1226, 70.99% of all vascular causes). Hematological and systemic causes, brain tumors, intracranial infections and cardiac causes were less commonly encountered risk factors and etiologies.
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spelling pubmed-92217372022-06-24 Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review Ciochon, Urszula Maria Bindslev, Julie Bolette Brix Hoei-Hansen, Christina Engel Truelsen, Thomas Clement Larsen, Vibeke Andrée Nielsen, Michael Bachmann Hansen, Adam Espe Diagnostics (Basel) Systematic Review Previous studies suggest that the most common cause of spontaneous intracerebral hemorrhage in children and adolescents is arteriovenous malformations (AVMs). However, an update containing recently published data on pediatric spontaneous intracranial hemorrhages is lacking. The aim of this study is to systematically analyze the published data on the etiologies and risk factors of pediatric spontaneous intracranial hemorrhage. This systematic review was performed in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A search in PubMed, Embase, Scopus, Web of Science and Cochrane Library was conducted aiming for articles published in year 2000 and later, containing data on etiology and risk factors of spontaneous intracranial hemorrhages in unselected cohorts of patients aged between 1 month and 18 years. As a result, forty studies were eligible for data extraction and final analysis. These included 7931 children and adolescents with 4009 reported etiologies and risk factors. A marked variety of reported etiologies and risk factors among studies was observed. Vascular etiologies were the most frequently reported cause of pediatric spontaneous intracranial hemorrhages (n = 1727, 43.08% of all identified etiologies or risk factors), with AVMs being the most common vascular cause (n = 1226, 70.99% of all vascular causes). Hematological and systemic causes, brain tumors, intracranial infections and cardiac causes were less commonly encountered risk factors and etiologies. MDPI 2022-06-13 /pmc/articles/PMC9221737/ /pubmed/35741269 http://dx.doi.org/10.3390/diagnostics12061459 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ciochon, Urszula Maria
Bindslev, Julie Bolette Brix
Hoei-Hansen, Christina Engel
Truelsen, Thomas Clement
Larsen, Vibeke Andrée
Nielsen, Michael Bachmann
Hansen, Adam Espe
Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
title Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
title_full Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
title_fullStr Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
title_full_unstemmed Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
title_short Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
title_sort causes and risk factors of pediatric spontaneous intracranial hemorrhage—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221737/
https://www.ncbi.nlm.nih.gov/pubmed/35741269
http://dx.doi.org/10.3390/diagnostics12061459
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