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The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and infl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221759/ https://www.ncbi.nlm.nih.gov/pubmed/35735622 http://dx.doi.org/10.3390/cimb44060181 |
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author | Otelea, Marina Ruxandra Nartea, Roxana Popescu, Florina Georgeta Covaleov, Anatoli Mitoiu, Brindusa Ilinca Nica, Adriana Sarah |
author_facet | Otelea, Marina Ruxandra Nartea, Roxana Popescu, Florina Georgeta Covaleov, Anatoli Mitoiu, Brindusa Ilinca Nica, Adriana Sarah |
author_sort | Otelea, Marina Ruxandra |
collection | PubMed |
description | An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and inflammation, and is a major risk factor for diabetes and cardiovascular diseases. Taking these elements into consideration, we conducted an extensive literature revision of the subject, considering as ectopic fat-related mechanisms the following: (a) the direct compression and the association with the metabolic syndrome of the fat deposition around the wrist, (b) the insulin resistance, dyslipidemia, inflammatory, and oxidative mechanisms related to the central deposition of the fat, (c) the impaired muscle contraction and metabolism related to myosteatosis. Each section presents the cellular pathways which are modified by the ectopic deposition of the adipose tissue and the impact in the pathogeny of the carpal tunnel syndrome. In conclusion, the experimental and clinical data support the epidemiological findings. Efforts to reduce the obesity epidemics will improve not only cardio-metabolic health but will reduce the burden of the disability-free life expectancy due to the carpal tunnel syndrome. |
format | Online Article Text |
id | pubmed-9221759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92217592022-06-24 The Pathological Links between Adiposity and the Carpal Tunnel Syndrome Otelea, Marina Ruxandra Nartea, Roxana Popescu, Florina Georgeta Covaleov, Anatoli Mitoiu, Brindusa Ilinca Nica, Adriana Sarah Curr Issues Mol Biol Review An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and inflammation, and is a major risk factor for diabetes and cardiovascular diseases. Taking these elements into consideration, we conducted an extensive literature revision of the subject, considering as ectopic fat-related mechanisms the following: (a) the direct compression and the association with the metabolic syndrome of the fat deposition around the wrist, (b) the insulin resistance, dyslipidemia, inflammatory, and oxidative mechanisms related to the central deposition of the fat, (c) the impaired muscle contraction and metabolism related to myosteatosis. Each section presents the cellular pathways which are modified by the ectopic deposition of the adipose tissue and the impact in the pathogeny of the carpal tunnel syndrome. In conclusion, the experimental and clinical data support the epidemiological findings. Efforts to reduce the obesity epidemics will improve not only cardio-metabolic health but will reduce the burden of the disability-free life expectancy due to the carpal tunnel syndrome. MDPI 2022-06-08 /pmc/articles/PMC9221759/ /pubmed/35735622 http://dx.doi.org/10.3390/cimb44060181 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Otelea, Marina Ruxandra Nartea, Roxana Popescu, Florina Georgeta Covaleov, Anatoli Mitoiu, Brindusa Ilinca Nica, Adriana Sarah The Pathological Links between Adiposity and the Carpal Tunnel Syndrome |
title | The Pathological Links between Adiposity and the Carpal Tunnel Syndrome |
title_full | The Pathological Links between Adiposity and the Carpal Tunnel Syndrome |
title_fullStr | The Pathological Links between Adiposity and the Carpal Tunnel Syndrome |
title_full_unstemmed | The Pathological Links between Adiposity and the Carpal Tunnel Syndrome |
title_short | The Pathological Links between Adiposity and the Carpal Tunnel Syndrome |
title_sort | pathological links between adiposity and the carpal tunnel syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221759/ https://www.ncbi.nlm.nih.gov/pubmed/35735622 http://dx.doi.org/10.3390/cimb44060181 |
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