Cargando…

The Pathological Links between Adiposity and the Carpal Tunnel Syndrome

An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and infl...

Descripción completa

Detalles Bibliográficos
Autores principales: Otelea, Marina Ruxandra, Nartea, Roxana, Popescu, Florina Georgeta, Covaleov, Anatoli, Mitoiu, Brindusa Ilinca, Nica, Adriana Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221759/
https://www.ncbi.nlm.nih.gov/pubmed/35735622
http://dx.doi.org/10.3390/cimb44060181
_version_ 1784732701579804672
author Otelea, Marina Ruxandra
Nartea, Roxana
Popescu, Florina Georgeta
Covaleov, Anatoli
Mitoiu, Brindusa Ilinca
Nica, Adriana Sarah
author_facet Otelea, Marina Ruxandra
Nartea, Roxana
Popescu, Florina Georgeta
Covaleov, Anatoli
Mitoiu, Brindusa Ilinca
Nica, Adriana Sarah
author_sort Otelea, Marina Ruxandra
collection PubMed
description An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and inflammation, and is a major risk factor for diabetes and cardiovascular diseases. Taking these elements into consideration, we conducted an extensive literature revision of the subject, considering as ectopic fat-related mechanisms the following: (a) the direct compression and the association with the metabolic syndrome of the fat deposition around the wrist, (b) the insulin resistance, dyslipidemia, inflammatory, and oxidative mechanisms related to the central deposition of the fat, (c) the impaired muscle contraction and metabolism related to myosteatosis. Each section presents the cellular pathways which are modified by the ectopic deposition of the adipose tissue and the impact in the pathogeny of the carpal tunnel syndrome. In conclusion, the experimental and clinical data support the epidemiological findings. Efforts to reduce the obesity epidemics will improve not only cardio-metabolic health but will reduce the burden of the disability-free life expectancy due to the carpal tunnel syndrome.
format Online
Article
Text
id pubmed-9221759
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92217592022-06-24 The Pathological Links between Adiposity and the Carpal Tunnel Syndrome Otelea, Marina Ruxandra Nartea, Roxana Popescu, Florina Georgeta Covaleov, Anatoli Mitoiu, Brindusa Ilinca Nica, Adriana Sarah Curr Issues Mol Biol Review An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and inflammation, and is a major risk factor for diabetes and cardiovascular diseases. Taking these elements into consideration, we conducted an extensive literature revision of the subject, considering as ectopic fat-related mechanisms the following: (a) the direct compression and the association with the metabolic syndrome of the fat deposition around the wrist, (b) the insulin resistance, dyslipidemia, inflammatory, and oxidative mechanisms related to the central deposition of the fat, (c) the impaired muscle contraction and metabolism related to myosteatosis. Each section presents the cellular pathways which are modified by the ectopic deposition of the adipose tissue and the impact in the pathogeny of the carpal tunnel syndrome. In conclusion, the experimental and clinical data support the epidemiological findings. Efforts to reduce the obesity epidemics will improve not only cardio-metabolic health but will reduce the burden of the disability-free life expectancy due to the carpal tunnel syndrome. MDPI 2022-06-08 /pmc/articles/PMC9221759/ /pubmed/35735622 http://dx.doi.org/10.3390/cimb44060181 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Otelea, Marina Ruxandra
Nartea, Roxana
Popescu, Florina Georgeta
Covaleov, Anatoli
Mitoiu, Brindusa Ilinca
Nica, Adriana Sarah
The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
title The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
title_full The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
title_fullStr The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
title_full_unstemmed The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
title_short The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
title_sort pathological links between adiposity and the carpal tunnel syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221759/
https://www.ncbi.nlm.nih.gov/pubmed/35735622
http://dx.doi.org/10.3390/cimb44060181
work_keys_str_mv AT oteleamarinaruxandra thepathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT nartearoxana thepathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT popescuflorinageorgeta thepathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT covaleovanatoli thepathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT mitoiubrindusailinca thepathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT nicaadrianasarah thepathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT oteleamarinaruxandra pathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT nartearoxana pathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT popescuflorinageorgeta pathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT covaleovanatoli pathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT mitoiubrindusailinca pathologicallinksbetweenadiposityandthecarpaltunnelsyndrome
AT nicaadrianasarah pathologicallinksbetweenadiposityandthecarpaltunnelsyndrome