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An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis

Introduction: With the increasing use of immune checkpoint inhibitors (ICI) for cancer, there is a growing burden on the healthcare system to provide care for the toxicities associated with these agents. Herein, we aim to identify and describe the distribution of encounters seen in an urgent care se...

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Autores principales: Liang, Kai-li, Tackett, Sean, Myers, Samantha, Brahmer, Julie R., Browner, Ilene S., Ettinger, David S., Forde, Patrick M., Hales, Russell K., Hann, Christine L., Lam, Vincent K., Marrone, Kristen A., Patel, Tricia, Peterson, Valerie, Sagorsky, Sarah, Turner, Michelle, Voong, Khinh R., Naidoo, Jarushka, Feliciano, Josephine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221771/
https://www.ncbi.nlm.nih.gov/pubmed/35735456
http://dx.doi.org/10.3390/curroncol29060347
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author Liang, Kai-li
Tackett, Sean
Myers, Samantha
Brahmer, Julie R.
Browner, Ilene S.
Ettinger, David S.
Forde, Patrick M.
Hales, Russell K.
Hann, Christine L.
Lam, Vincent K.
Marrone, Kristen A.
Patel, Tricia
Peterson, Valerie
Sagorsky, Sarah
Turner, Michelle
Voong, Khinh R.
Naidoo, Jarushka
Feliciano, Josephine L.
author_facet Liang, Kai-li
Tackett, Sean
Myers, Samantha
Brahmer, Julie R.
Browner, Ilene S.
Ettinger, David S.
Forde, Patrick M.
Hales, Russell K.
Hann, Christine L.
Lam, Vincent K.
Marrone, Kristen A.
Patel, Tricia
Peterson, Valerie
Sagorsky, Sarah
Turner, Michelle
Voong, Khinh R.
Naidoo, Jarushka
Feliciano, Josephine L.
author_sort Liang, Kai-li
collection PubMed
description Introduction: With the increasing use of immune checkpoint inhibitors (ICI) for cancer, there is a growing burden on the healthcare system to provide care for the toxicities associated with these agents. Herein, we aim to identify and describe the distribution of encounters seen in an urgent care setting for immune-related adverse events (irAEs) and the clinical outcomes from irAE management. Methods: Patient demographics, disease characteristics, and treatment data were collected retrospectively from encounters at an oncology Urgent Care Clinic (UCC) from a single tertiary center for upper aerodigestive malignancies from 1 July 2018 to 30 June 2019. Data were summarized using descriptive statistics with odds ratios for associations between patient features and hospitalization after UCC evaluation. Results: We identified 494 encounters from 289 individual patients over the study period. A history of ICI therapy was noted in 34% (n = 170/494) of encounters and 29 encounters (29/170, 17%) were confirmed and treated as irAEs. For those treated for irAEs, the majority (n = 19/29; 66%) were discharged home. Having an irAE was associated with an increased risk of hospitalization compared to non-irAEs (OR 5.66; 95% CI 2.15–14.89; p < 0.001). Conclusion: In this single institution experience, the majority of UCC encounters for confirmed irAEs were safely managed within the UCC. In ICI-treated patients, having an irAE was associated with an increased risk of hospitalization versus non-irAEs.
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spelling pubmed-92217712022-06-24 An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis Liang, Kai-li Tackett, Sean Myers, Samantha Brahmer, Julie R. Browner, Ilene S. Ettinger, David S. Forde, Patrick M. Hales, Russell K. Hann, Christine L. Lam, Vincent K. Marrone, Kristen A. Patel, Tricia Peterson, Valerie Sagorsky, Sarah Turner, Michelle Voong, Khinh R. Naidoo, Jarushka Feliciano, Josephine L. Curr Oncol Article Introduction: With the increasing use of immune checkpoint inhibitors (ICI) for cancer, there is a growing burden on the healthcare system to provide care for the toxicities associated with these agents. Herein, we aim to identify and describe the distribution of encounters seen in an urgent care setting for immune-related adverse events (irAEs) and the clinical outcomes from irAE management. Methods: Patient demographics, disease characteristics, and treatment data were collected retrospectively from encounters at an oncology Urgent Care Clinic (UCC) from a single tertiary center for upper aerodigestive malignancies from 1 July 2018 to 30 June 2019. Data were summarized using descriptive statistics with odds ratios for associations between patient features and hospitalization after UCC evaluation. Results: We identified 494 encounters from 289 individual patients over the study period. A history of ICI therapy was noted in 34% (n = 170/494) of encounters and 29 encounters (29/170, 17%) were confirmed and treated as irAEs. For those treated for irAEs, the majority (n = 19/29; 66%) were discharged home. Having an irAE was associated with an increased risk of hospitalization compared to non-irAEs (OR 5.66; 95% CI 2.15–14.89; p < 0.001). Conclusion: In this single institution experience, the majority of UCC encounters for confirmed irAEs were safely managed within the UCC. In ICI-treated patients, having an irAE was associated with an increased risk of hospitalization versus non-irAEs. MDPI 2022-06-17 /pmc/articles/PMC9221771/ /pubmed/35735456 http://dx.doi.org/10.3390/curroncol29060347 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liang, Kai-li
Tackett, Sean
Myers, Samantha
Brahmer, Julie R.
Browner, Ilene S.
Ettinger, David S.
Forde, Patrick M.
Hales, Russell K.
Hann, Christine L.
Lam, Vincent K.
Marrone, Kristen A.
Patel, Tricia
Peterson, Valerie
Sagorsky, Sarah
Turner, Michelle
Voong, Khinh R.
Naidoo, Jarushka
Feliciano, Josephine L.
An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis
title An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis
title_full An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis
title_fullStr An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis
title_full_unstemmed An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis
title_short An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis
title_sort oncology urgent care clinic for the management of immune-related adverse events: a descriptive analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221771/
https://www.ncbi.nlm.nih.gov/pubmed/35735456
http://dx.doi.org/10.3390/curroncol29060347
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