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Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC

Objectives: To explore the potential of radiomics on gadoxetate disodium-enhanced MRI for predicting hepatocellular carcinoma (HCC) response after transarterial embolization (TAE). Methods: This retrospective study included cirrhotic patients treated with TAE for unifocal HCC naïve to treatments. Ea...

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Autores principales: Cannella, Roberto, Cammà, Carla, Matteini, Francesco, Celsa, Ciro, Giuffrida, Paolo, Enea, Marco, Comelli, Albert, Stefano, Alessandro, Cammà, Calogero, Midiri, Massimo, Lagalla, Roberto, Brancatelli, Giuseppe, Vernuccio, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221802/
https://www.ncbi.nlm.nih.gov/pubmed/35741118
http://dx.doi.org/10.3390/diagnostics12061308
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author Cannella, Roberto
Cammà, Carla
Matteini, Francesco
Celsa, Ciro
Giuffrida, Paolo
Enea, Marco
Comelli, Albert
Stefano, Alessandro
Cammà, Calogero
Midiri, Massimo
Lagalla, Roberto
Brancatelli, Giuseppe
Vernuccio, Federica
author_facet Cannella, Roberto
Cammà, Carla
Matteini, Francesco
Celsa, Ciro
Giuffrida, Paolo
Enea, Marco
Comelli, Albert
Stefano, Alessandro
Cammà, Calogero
Midiri, Massimo
Lagalla, Roberto
Brancatelli, Giuseppe
Vernuccio, Federica
author_sort Cannella, Roberto
collection PubMed
description Objectives: To explore the potential of radiomics on gadoxetate disodium-enhanced MRI for predicting hepatocellular carcinoma (HCC) response after transarterial embolization (TAE). Methods: This retrospective study included cirrhotic patients treated with TAE for unifocal HCC naïve to treatments. Each patient underwent gadoxetate disodium-enhanced MRI. Radiomics analysis was performed by segmenting the lesions on portal venous (PVP), 3-min transitional, and 20-min hepatobiliary (HBP) phases. Clinical data, laboratory variables, and qualitative features based on LI-RADSv2018 were assessed. Reference standard was based on mRECIST response criteria. Two different radiomics models were constructed, a statistical model based on logistic regression with elastic net penalty (model 1) and a computational model based on a hybrid descriptive-inferential feature extraction method (model 2). Areas under the ROC curves (AUC) were calculated. Results: The final population included 51 patients with HCC (median size 20 mm). Complete and objective responses were obtained in 14 (27.4%) and 29 (56.9%) patients, respectively. Model 1 showed the highest performance on PVP for predicting objective response with an AUC of 0.733, sensitivity of 100%, and specificity of 40.0% in the test set. Model 2 demonstrated similar performances on PVP and HBP for predicting objective response, with an AUC of 0.791, sensitivity of 71.3%, specificity of 61.7% on PVP, and AUC of 0.790, sensitivity of 58.8%, and specificity of 90.1% on HBP. Conclusions: Radiomics models based on gadoxetate disodium-enhanced MRI can achieve good performance for predicting response of HCCs treated with TAE.
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spelling pubmed-92218022022-06-24 Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC Cannella, Roberto Cammà, Carla Matteini, Francesco Celsa, Ciro Giuffrida, Paolo Enea, Marco Comelli, Albert Stefano, Alessandro Cammà, Calogero Midiri, Massimo Lagalla, Roberto Brancatelli, Giuseppe Vernuccio, Federica Diagnostics (Basel) Article Objectives: To explore the potential of radiomics on gadoxetate disodium-enhanced MRI for predicting hepatocellular carcinoma (HCC) response after transarterial embolization (TAE). Methods: This retrospective study included cirrhotic patients treated with TAE for unifocal HCC naïve to treatments. Each patient underwent gadoxetate disodium-enhanced MRI. Radiomics analysis was performed by segmenting the lesions on portal venous (PVP), 3-min transitional, and 20-min hepatobiliary (HBP) phases. Clinical data, laboratory variables, and qualitative features based on LI-RADSv2018 were assessed. Reference standard was based on mRECIST response criteria. Two different radiomics models were constructed, a statistical model based on logistic regression with elastic net penalty (model 1) and a computational model based on a hybrid descriptive-inferential feature extraction method (model 2). Areas under the ROC curves (AUC) were calculated. Results: The final population included 51 patients with HCC (median size 20 mm). Complete and objective responses were obtained in 14 (27.4%) and 29 (56.9%) patients, respectively. Model 1 showed the highest performance on PVP for predicting objective response with an AUC of 0.733, sensitivity of 100%, and specificity of 40.0% in the test set. Model 2 demonstrated similar performances on PVP and HBP for predicting objective response, with an AUC of 0.791, sensitivity of 71.3%, specificity of 61.7% on PVP, and AUC of 0.790, sensitivity of 58.8%, and specificity of 90.1% on HBP. Conclusions: Radiomics models based on gadoxetate disodium-enhanced MRI can achieve good performance for predicting response of HCCs treated with TAE. MDPI 2022-05-24 /pmc/articles/PMC9221802/ /pubmed/35741118 http://dx.doi.org/10.3390/diagnostics12061308 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cannella, Roberto
Cammà, Carla
Matteini, Francesco
Celsa, Ciro
Giuffrida, Paolo
Enea, Marco
Comelli, Albert
Stefano, Alessandro
Cammà, Calogero
Midiri, Massimo
Lagalla, Roberto
Brancatelli, Giuseppe
Vernuccio, Federica
Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC
title Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC
title_full Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC
title_fullStr Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC
title_full_unstemmed Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC
title_short Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC
title_sort radiomics analysis on gadoxetate disodium-enhanced mri predicts response to transarterial embolization in patients with hcc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221802/
https://www.ncbi.nlm.nih.gov/pubmed/35741118
http://dx.doi.org/10.3390/diagnostics12061308
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