LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene t...

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Autores principales: Gogoleva, Violetta S., Kuprash, Dmitry V., Grivennikov, Sergei I., Tumanov, Alexei V., Kruglov, Andrey A., Nedospasov, Sergei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221848/
https://www.ncbi.nlm.nih.gov/pubmed/35741098
http://dx.doi.org/10.3390/cells11121970
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author Gogoleva, Violetta S.
Kuprash, Dmitry V.
Grivennikov, Sergei I.
Tumanov, Alexei V.
Kruglov, Andrey A.
Nedospasov, Sergei A.
author_facet Gogoleva, Violetta S.
Kuprash, Dmitry V.
Grivennikov, Sergei I.
Tumanov, Alexei V.
Kruglov, Andrey A.
Nedospasov, Sergei A.
author_sort Gogoleva, Violetta S.
collection PubMed
description TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.
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spelling pubmed-92218482022-06-24 LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis Gogoleva, Violetta S. Kuprash, Dmitry V. Grivennikov, Sergei I. Tumanov, Alexei V. Kruglov, Andrey A. Nedospasov, Sergei A. Cells Communication TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis. MDPI 2022-06-19 /pmc/articles/PMC9221848/ /pubmed/35741098 http://dx.doi.org/10.3390/cells11121970 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gogoleva, Violetta S.
Kuprash, Dmitry V.
Grivennikov, Sergei I.
Tumanov, Alexei V.
Kruglov, Andrey A.
Nedospasov, Sergei A.
LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
title LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
title_full LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
title_fullStr LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
title_full_unstemmed LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
title_short LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
title_sort ltα, tnf, and ilc3 in peyer’s patch organogenesis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221848/
https://www.ncbi.nlm.nih.gov/pubmed/35741098
http://dx.doi.org/10.3390/cells11121970
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