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An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania

Background and Objectives: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regim...

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Autores principales: Cocuz, Iuliu Gabriel, Cocuz, Maria Elena, Sabău, Adrian-Horațiu, Niculescu, Raluca, Tinca, Andreea Cătălina, Vunvulea, Vlad, Budin, Corina Eugenia, Șincu, Mihaela Cornelia, Popelea, Maria Cătălina, Cotoi, Ovidiu Simion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221858/
https://www.ncbi.nlm.nih.gov/pubmed/35735659
http://dx.doi.org/10.3390/dermatopathology9020023
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author Cocuz, Iuliu Gabriel
Cocuz, Maria Elena
Sabău, Adrian-Horațiu
Niculescu, Raluca
Tinca, Andreea Cătălina
Vunvulea, Vlad
Budin, Corina Eugenia
Șincu, Mihaela Cornelia
Popelea, Maria Cătălina
Cotoi, Ovidiu Simion
author_facet Cocuz, Iuliu Gabriel
Cocuz, Maria Elena
Sabău, Adrian-Horațiu
Niculescu, Raluca
Tinca, Andreea Cătălina
Vunvulea, Vlad
Budin, Corina Eugenia
Șincu, Mihaela Cornelia
Popelea, Maria Cătălina
Cotoi, Ovidiu Simion
author_sort Cocuz, Iuliu Gabriel
collection PubMed
description Background and Objectives: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regime for patients who have been diagnosed with this type of cancer. The objective of the present study was to establish the statistical value of prediction for certain sociodemographic characteristics (age category and environment of origin) and histopathological parameters of the subjects that could be related to the incidence of diagnosis with certain histopathological subtypes of BCC. Materials and Methods: In order to verify the veracity of the established research hypotheses, we conducted a retrospective study based on the histopathological reports of 216 patients who were treated at the Pathology Department of Mureș Clinical County Hospital. Results: Cystic BCC is higher in patients who are older than 71 years of age, and the superficial multicentric and keratotic subtypes are more frequently diagnosed in urban areas. Patients who have been diagnosed with the superficial multicentric BCC subtype are not usually very old in contrast to the patients who tend to be diagnosed with the cystic BCC subtype. The nodular BCC subtype is positively associated with ulceration (p = 0.004); the superficial multicentric BCC subtype is positively associated with intra- and peritumoral inflammatory infiltrate (p = 0.022, p = 0.034) and negatively associated with ulceration (r = −0.218, p = 0.001). The infiltrative BCC subtype is positively associated with ulceration (p = 0.021), and the keratotic BCC subtype is positively associated with peritumoral inflammatory infiltrate (p = 0.02). Conclusions: Depending on each patient’s epidemiological and sociodemographic data, a pattern can be established regarding the appropriate clinical and treatment approaches for that patient, which can be supported based on the implications of the histopathological diagnostic. This can lead to an improvement in the patient’s quality of life and increased satisfaction with the provided medical services.
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spelling pubmed-92218582022-06-24 An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania Cocuz, Iuliu Gabriel Cocuz, Maria Elena Sabău, Adrian-Horațiu Niculescu, Raluca Tinca, Andreea Cătălina Vunvulea, Vlad Budin, Corina Eugenia Șincu, Mihaela Cornelia Popelea, Maria Cătălina Cotoi, Ovidiu Simion Dermatopathology (Basel) Article Background and Objectives: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regime for patients who have been diagnosed with this type of cancer. The objective of the present study was to establish the statistical value of prediction for certain sociodemographic characteristics (age category and environment of origin) and histopathological parameters of the subjects that could be related to the incidence of diagnosis with certain histopathological subtypes of BCC. Materials and Methods: In order to verify the veracity of the established research hypotheses, we conducted a retrospective study based on the histopathological reports of 216 patients who were treated at the Pathology Department of Mureș Clinical County Hospital. Results: Cystic BCC is higher in patients who are older than 71 years of age, and the superficial multicentric and keratotic subtypes are more frequently diagnosed in urban areas. Patients who have been diagnosed with the superficial multicentric BCC subtype are not usually very old in contrast to the patients who tend to be diagnosed with the cystic BCC subtype. The nodular BCC subtype is positively associated with ulceration (p = 0.004); the superficial multicentric BCC subtype is positively associated with intra- and peritumoral inflammatory infiltrate (p = 0.022, p = 0.034) and negatively associated with ulceration (r = −0.218, p = 0.001). The infiltrative BCC subtype is positively associated with ulceration (p = 0.021), and the keratotic BCC subtype is positively associated with peritumoral inflammatory infiltrate (p = 0.02). Conclusions: Depending on each patient’s epidemiological and sociodemographic data, a pattern can be established regarding the appropriate clinical and treatment approaches for that patient, which can be supported based on the implications of the histopathological diagnostic. This can lead to an improvement in the patient’s quality of life and increased satisfaction with the provided medical services. MDPI 2022-06-18 /pmc/articles/PMC9221858/ /pubmed/35735659 http://dx.doi.org/10.3390/dermatopathology9020023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cocuz, Iuliu Gabriel
Cocuz, Maria Elena
Sabău, Adrian-Horațiu
Niculescu, Raluca
Tinca, Andreea Cătălina
Vunvulea, Vlad
Budin, Corina Eugenia
Șincu, Mihaela Cornelia
Popelea, Maria Cătălina
Cotoi, Ovidiu Simion
An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania
title An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania
title_full An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania
title_fullStr An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania
title_full_unstemmed An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania
title_short An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania
title_sort up-to-date correlation of epidemiological and histopathological characteristics of basal cell carcinoma of the skin in a county hospital in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221858/
https://www.ncbi.nlm.nih.gov/pubmed/35735659
http://dx.doi.org/10.3390/dermatopathology9020023
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