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Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas

The aim of the study was to evaluate the relationship between tumor blood flow (TBF) measured by the pseudo-continuous arterial spin labeling (PCASL) method and IDH1 mutation status of gliomas as well as Ki-67 proliferative index. Methods. The study included 116 patients with newly diagnosed gliomas...

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Autores principales: Batalov, Artem I., Zakharova, Natalia E., Chekhonin, Ivan V., Pogosbekyan, Eduard L., Sudarikova, Anna V., Goryainov, Sergey A., Shulgina, Anna A., Belyaev, Artem Yu., Usachev, Dmirti Yu., Pronin, Igor N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221904/
https://www.ncbi.nlm.nih.gov/pubmed/35741254
http://dx.doi.org/10.3390/diagnostics12061444
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author Batalov, Artem I.
Zakharova, Natalia E.
Chekhonin, Ivan V.
Pogosbekyan, Eduard L.
Sudarikova, Anna V.
Goryainov, Sergey A.
Shulgina, Anna A.
Belyaev, Artem Yu.
Usachev, Dmirti Yu.
Pronin, Igor N.
author_facet Batalov, Artem I.
Zakharova, Natalia E.
Chekhonin, Ivan V.
Pogosbekyan, Eduard L.
Sudarikova, Anna V.
Goryainov, Sergey A.
Shulgina, Anna A.
Belyaev, Artem Yu.
Usachev, Dmirti Yu.
Pronin, Igor N.
author_sort Batalov, Artem I.
collection PubMed
description The aim of the study was to evaluate the relationship between tumor blood flow (TBF) measured by the pseudo-continuous arterial spin labeling (PCASL) method and IDH1 mutation status of gliomas as well as Ki-67 proliferative index. Methods. The study included 116 patients with newly diagnosed gliomas of various grades. They received no chemotherapy or radiotherapy before MRI. IDH1 status assessment was performed after tumor removal in 106 cases—48 patients were diagnosed with wildtype gliomas (Grade 1–2—6 patients, Grade 3–4—42 patients) and 58 patients were diagnosed with mutant forms of gliomas (Grade 1–2—28 patients, Grade 3–4—30 patients). In 64 cases out of 116 Ki-67 index was measured. Absolute and normalized tumor blood flow values were measured on 3D PCASL maps. Results. TBF and normalized TBF (nTBF) in wildtype gliomas were significantly higher than in IDH1-mutant gliomas (p < 0.001). ASL perfusion showed high values of sensitivity and specificity in the differential diagnosis of gliomas with distinct IDH1 status (for TBF: specificity 75%, sensitivity 77.6%, AUC 0.783, cutoff 80.57 mL/100 g/min, for nTBF: specificity 77.1%, sensitivity 79.3%, AUC 0.791, cutoff 4.7). TBF and nTBF in wildtype high-grade gliomas (HGG) were significantly higher than in mutant forms (p < 0.001). ASL perfusion showed the following values of sensitivity and specificity in the diagnosis of mutant HGG and wildtype HGG (for TBF: specificity 83.3%, sensitivity 60%, AUC 0.719, cutoff 84.18 mL/100 g/min, for nTBF: specificity 88.1%, sensitivity 60%, AUC 0.729, cutoff 4.7). There was a significant positive correlation between tumor blood flow and Ki-67 (for TBF Rs = 0.63, for nTBF Rs = 0.61). Conclusion. ASL perfusion may be an informative factor in determining the IDH1 status in brain gliomas preoperative and tumor proliferative activity.
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spelling pubmed-92219042022-06-24 Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas Batalov, Artem I. Zakharova, Natalia E. Chekhonin, Ivan V. Pogosbekyan, Eduard L. Sudarikova, Anna V. Goryainov, Sergey A. Shulgina, Anna A. Belyaev, Artem Yu. Usachev, Dmirti Yu. Pronin, Igor N. Diagnostics (Basel) Article The aim of the study was to evaluate the relationship between tumor blood flow (TBF) measured by the pseudo-continuous arterial spin labeling (PCASL) method and IDH1 mutation status of gliomas as well as Ki-67 proliferative index. Methods. The study included 116 patients with newly diagnosed gliomas of various grades. They received no chemotherapy or radiotherapy before MRI. IDH1 status assessment was performed after tumor removal in 106 cases—48 patients were diagnosed with wildtype gliomas (Grade 1–2—6 patients, Grade 3–4—42 patients) and 58 patients were diagnosed with mutant forms of gliomas (Grade 1–2—28 patients, Grade 3–4—30 patients). In 64 cases out of 116 Ki-67 index was measured. Absolute and normalized tumor blood flow values were measured on 3D PCASL maps. Results. TBF and normalized TBF (nTBF) in wildtype gliomas were significantly higher than in IDH1-mutant gliomas (p < 0.001). ASL perfusion showed high values of sensitivity and specificity in the differential diagnosis of gliomas with distinct IDH1 status (for TBF: specificity 75%, sensitivity 77.6%, AUC 0.783, cutoff 80.57 mL/100 g/min, for nTBF: specificity 77.1%, sensitivity 79.3%, AUC 0.791, cutoff 4.7). TBF and nTBF in wildtype high-grade gliomas (HGG) were significantly higher than in mutant forms (p < 0.001). ASL perfusion showed the following values of sensitivity and specificity in the diagnosis of mutant HGG and wildtype HGG (for TBF: specificity 83.3%, sensitivity 60%, AUC 0.719, cutoff 84.18 mL/100 g/min, for nTBF: specificity 88.1%, sensitivity 60%, AUC 0.729, cutoff 4.7). There was a significant positive correlation between tumor blood flow and Ki-67 (for TBF Rs = 0.63, for nTBF Rs = 0.61). Conclusion. ASL perfusion may be an informative factor in determining the IDH1 status in brain gliomas preoperative and tumor proliferative activity. MDPI 2022-06-12 /pmc/articles/PMC9221904/ /pubmed/35741254 http://dx.doi.org/10.3390/diagnostics12061444 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Batalov, Artem I.
Zakharova, Natalia E.
Chekhonin, Ivan V.
Pogosbekyan, Eduard L.
Sudarikova, Anna V.
Goryainov, Sergey A.
Shulgina, Anna A.
Belyaev, Artem Yu.
Usachev, Dmirti Yu.
Pronin, Igor N.
Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas
title Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas
title_full Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas
title_fullStr Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas
title_full_unstemmed Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas
title_short Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas
title_sort arterial spin labeling perfusion in determining the idh1 status and ki-67 index in brain gliomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221904/
https://www.ncbi.nlm.nih.gov/pubmed/35741254
http://dx.doi.org/10.3390/diagnostics12061444
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