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Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases
Chronic lung diseases such as asthma, chronic obstructive pulmonary disease, lung cancer, and the recently emerged COVID-19, are a huge threat to human health, and among the leading causes of global morbidity and mortality every year. Despite availability of various conventional therapeutics, many p...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221924/ https://www.ncbi.nlm.nih.gov/pubmed/35774068 http://dx.doi.org/10.1016/j.jddst.2022.103541 |
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author | Chan, Yinghan Singh, Sachin Kumar Gulati, Monica Wadhwa, Sheetu Prasher, Parteek Kumar, Deepak Kumar, Avvaru Praveen Gupta, Gaurav Kuppusamy, Gowthamarajan Haghi, Mehra George Oliver, Brian Gregory Adams, Jon Chellappan, Dinesh Kumar Dua, Kamal |
author_facet | Chan, Yinghan Singh, Sachin Kumar Gulati, Monica Wadhwa, Sheetu Prasher, Parteek Kumar, Deepak Kumar, Avvaru Praveen Gupta, Gaurav Kuppusamy, Gowthamarajan Haghi, Mehra George Oliver, Brian Gregory Adams, Jon Chellappan, Dinesh Kumar Dua, Kamal |
author_sort | Chan, Yinghan |
collection | PubMed |
description | Chronic lung diseases such as asthma, chronic obstructive pulmonary disease, lung cancer, and the recently emerged COVID-19, are a huge threat to human health, and among the leading causes of global morbidity and mortality every year. Despite availability of various conventional therapeutics, many patients remain poorly controlled and have a poor quality of life. Furthermore, the treatment and diagnosis of these diseases are becoming increasingly challenging. In the recent years, the application of nanomedicine has become increasingly popular as a novel strategy for diagnosis, treatment, prevention, as well as follow-up of chronic lung diseases. This is attributed to the ability of nanoscale drug carriers to achieve targeted delivery of therapeutic moieties with specificity to diseased site within the lung, thereby enhancing therapeutic outcomes of conventional therapies whilst minimizing the risks of adverse reactions. For this instance, monoolein is a polar lipid nanomaterial best known for its versatility, thermodynamic stability, biocompatibility, and biodegradability. As such, it is commonly employed in liquid crystalline systems for various drug delivery applications. In this review, we present the applications of monoolein as a novel nanomaterial-based strategy for targeted drug delivery with the potential to revolutionize therapeutic approaches in chronic lung diseases. |
format | Online Article Text |
id | pubmed-9221924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92219242022-06-24 Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases Chan, Yinghan Singh, Sachin Kumar Gulati, Monica Wadhwa, Sheetu Prasher, Parteek Kumar, Deepak Kumar, Avvaru Praveen Gupta, Gaurav Kuppusamy, Gowthamarajan Haghi, Mehra George Oliver, Brian Gregory Adams, Jon Chellappan, Dinesh Kumar Dua, Kamal J Drug Deliv Sci Technol Review Article Chronic lung diseases such as asthma, chronic obstructive pulmonary disease, lung cancer, and the recently emerged COVID-19, are a huge threat to human health, and among the leading causes of global morbidity and mortality every year. Despite availability of various conventional therapeutics, many patients remain poorly controlled and have a poor quality of life. Furthermore, the treatment and diagnosis of these diseases are becoming increasingly challenging. In the recent years, the application of nanomedicine has become increasingly popular as a novel strategy for diagnosis, treatment, prevention, as well as follow-up of chronic lung diseases. This is attributed to the ability of nanoscale drug carriers to achieve targeted delivery of therapeutic moieties with specificity to diseased site within the lung, thereby enhancing therapeutic outcomes of conventional therapies whilst minimizing the risks of adverse reactions. For this instance, monoolein is a polar lipid nanomaterial best known for its versatility, thermodynamic stability, biocompatibility, and biodegradability. As such, it is commonly employed in liquid crystalline systems for various drug delivery applications. In this review, we present the applications of monoolein as a novel nanomaterial-based strategy for targeted drug delivery with the potential to revolutionize therapeutic approaches in chronic lung diseases. Elsevier B.V. 2022-08 2022-06-23 /pmc/articles/PMC9221924/ /pubmed/35774068 http://dx.doi.org/10.1016/j.jddst.2022.103541 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Article Chan, Yinghan Singh, Sachin Kumar Gulati, Monica Wadhwa, Sheetu Prasher, Parteek Kumar, Deepak Kumar, Avvaru Praveen Gupta, Gaurav Kuppusamy, Gowthamarajan Haghi, Mehra George Oliver, Brian Gregory Adams, Jon Chellappan, Dinesh Kumar Dua, Kamal Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
title | Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
title_full | Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
title_fullStr | Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
title_full_unstemmed | Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
title_short | Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
title_sort | advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221924/ https://www.ncbi.nlm.nih.gov/pubmed/35774068 http://dx.doi.org/10.1016/j.jddst.2022.103541 |
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