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Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study

The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin(®)) in pos...

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Autores principales: Laza, Georgeta-Maria, Sufaru, Irina-Georgeta, Martu, Maria-Alexandra, Martu, Cristian, Diaconu-Popa, Diana Antonela, Jelihovschi, Igor, Martu, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221947/
https://www.ncbi.nlm.nih.gov/pubmed/35741120
http://dx.doi.org/10.3390/diagnostics12061310
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author Laza, Georgeta-Maria
Sufaru, Irina-Georgeta
Martu, Maria-Alexandra
Martu, Cristian
Diaconu-Popa, Diana Antonela
Jelihovschi, Igor
Martu, Silvia
author_facet Laza, Georgeta-Maria
Sufaru, Irina-Georgeta
Martu, Maria-Alexandra
Martu, Cristian
Diaconu-Popa, Diana Antonela
Jelihovschi, Igor
Martu, Silvia
author_sort Laza, Georgeta-Maria
collection PubMed
description The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin(®)) in post-menopausal female patients with moderate and severe periodontitis. Probing depth, clinical attachment levels and bleeding on probing index, along with BANA tests for Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, were performed before and at 3 months after a combined treatment of scaling, root planing (SRP), and Arestin(®) placed in deep periodontal pockets. The association between SRP and Arestin(®) exerted significant improvements in terms of clinical periodontal parameters, as well as significant reductions in the red complex bacteria detection.
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spelling pubmed-92219472022-06-24 Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study Laza, Georgeta-Maria Sufaru, Irina-Georgeta Martu, Maria-Alexandra Martu, Cristian Diaconu-Popa, Diana Antonela Jelihovschi, Igor Martu, Silvia Diagnostics (Basel) Article The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin(®)) in post-menopausal female patients with moderate and severe periodontitis. Probing depth, clinical attachment levels and bleeding on probing index, along with BANA tests for Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, were performed before and at 3 months after a combined treatment of scaling, root planing (SRP), and Arestin(®) placed in deep periodontal pockets. The association between SRP and Arestin(®) exerted significant improvements in terms of clinical periodontal parameters, as well as significant reductions in the red complex bacteria detection. MDPI 2022-05-24 /pmc/articles/PMC9221947/ /pubmed/35741120 http://dx.doi.org/10.3390/diagnostics12061310 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Laza, Georgeta-Maria
Sufaru, Irina-Georgeta
Martu, Maria-Alexandra
Martu, Cristian
Diaconu-Popa, Diana Antonela
Jelihovschi, Igor
Martu, Silvia
Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
title Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
title_full Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
title_fullStr Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
title_full_unstemmed Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
title_short Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
title_sort effects of locally delivered minocycline microspheres in postmenopausal female patients with periodontitis: a clinical and microbiological study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221947/
https://www.ncbi.nlm.nih.gov/pubmed/35741120
http://dx.doi.org/10.3390/diagnostics12061310
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