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Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study
The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin(®)) in pos...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221947/ https://www.ncbi.nlm.nih.gov/pubmed/35741120 http://dx.doi.org/10.3390/diagnostics12061310 |
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author | Laza, Georgeta-Maria Sufaru, Irina-Georgeta Martu, Maria-Alexandra Martu, Cristian Diaconu-Popa, Diana Antonela Jelihovschi, Igor Martu, Silvia |
author_facet | Laza, Georgeta-Maria Sufaru, Irina-Georgeta Martu, Maria-Alexandra Martu, Cristian Diaconu-Popa, Diana Antonela Jelihovschi, Igor Martu, Silvia |
author_sort | Laza, Georgeta-Maria |
collection | PubMed |
description | The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin(®)) in post-menopausal female patients with moderate and severe periodontitis. Probing depth, clinical attachment levels and bleeding on probing index, along with BANA tests for Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, were performed before and at 3 months after a combined treatment of scaling, root planing (SRP), and Arestin(®) placed in deep periodontal pockets. The association between SRP and Arestin(®) exerted significant improvements in terms of clinical periodontal parameters, as well as significant reductions in the red complex bacteria detection. |
format | Online Article Text |
id | pubmed-9221947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92219472022-06-24 Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study Laza, Georgeta-Maria Sufaru, Irina-Georgeta Martu, Maria-Alexandra Martu, Cristian Diaconu-Popa, Diana Antonela Jelihovschi, Igor Martu, Silvia Diagnostics (Basel) Article The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin(®)) in post-menopausal female patients with moderate and severe periodontitis. Probing depth, clinical attachment levels and bleeding on probing index, along with BANA tests for Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, were performed before and at 3 months after a combined treatment of scaling, root planing (SRP), and Arestin(®) placed in deep periodontal pockets. The association between SRP and Arestin(®) exerted significant improvements in terms of clinical periodontal parameters, as well as significant reductions in the red complex bacteria detection. MDPI 2022-05-24 /pmc/articles/PMC9221947/ /pubmed/35741120 http://dx.doi.org/10.3390/diagnostics12061310 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Laza, Georgeta-Maria Sufaru, Irina-Georgeta Martu, Maria-Alexandra Martu, Cristian Diaconu-Popa, Diana Antonela Jelihovschi, Igor Martu, Silvia Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study |
title | Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study |
title_full | Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study |
title_fullStr | Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study |
title_full_unstemmed | Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study |
title_short | Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study |
title_sort | effects of locally delivered minocycline microspheres in postmenopausal female patients with periodontitis: a clinical and microbiological study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221947/ https://www.ncbi.nlm.nih.gov/pubmed/35741120 http://dx.doi.org/10.3390/diagnostics12061310 |
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