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Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations

Acute Eosinophilic Pneumonia (AEP) is a rare idiopathic disease caused by an accumulation of eosinophils in the pulmonary alveoli and interstitial tissue of the lungs. The onset of symptoms is acute; some patients develop respiratory failure. The diagnosis is based on clinical symptoms, diffuse inte...

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Autores principales: Jankowska, Ewa, Bartoszuk, Iwona, Lewandowska, Katarzyna, Dybowska, Małgorzata, Opoka, Lucyna, Tomkowski, Witold, Szturmowicz, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221981/
https://www.ncbi.nlm.nih.gov/pubmed/35741235
http://dx.doi.org/10.3390/diagnostics12061425
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author Jankowska, Ewa
Bartoszuk, Iwona
Lewandowska, Katarzyna
Dybowska, Małgorzata
Opoka, Lucyna
Tomkowski, Witold
Szturmowicz, Monika
author_facet Jankowska, Ewa
Bartoszuk, Iwona
Lewandowska, Katarzyna
Dybowska, Małgorzata
Opoka, Lucyna
Tomkowski, Witold
Szturmowicz, Monika
author_sort Jankowska, Ewa
collection PubMed
description Acute Eosinophilic Pneumonia (AEP) is a rare idiopathic disease caused by an accumulation of eosinophils in the pulmonary alveoli and interstitial tissue of the lungs. The onset of symptoms is acute; some patients develop respiratory failure. The diagnosis is based on clinical symptoms, diffuse interstitial infiltrates in the lungs on imaging studies, and eosinophilia exceeding 25% on bronchoalveolar lavage or pleural fluid smear. Smokers are primarily at increased risk for the disease. We present a case of venous thromboembolic disease (VTE) that developed in the course of AEP in a previously healthy male smoker. Complete remission of the disease was achieved with anticoagulation therapy combined with a low dose of steroids. Surprisingly, further diagnostics revealed the presence of thrombophilia: antithrombin (AT) deficiency and increased homocysteine level. According to our knowledge, this is the first case of VTE diagnosed in the course of AEP combined with thrombophilia.
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spelling pubmed-92219812022-06-24 Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations Jankowska, Ewa Bartoszuk, Iwona Lewandowska, Katarzyna Dybowska, Małgorzata Opoka, Lucyna Tomkowski, Witold Szturmowicz, Monika Diagnostics (Basel) Case Report Acute Eosinophilic Pneumonia (AEP) is a rare idiopathic disease caused by an accumulation of eosinophils in the pulmonary alveoli and interstitial tissue of the lungs. The onset of symptoms is acute; some patients develop respiratory failure. The diagnosis is based on clinical symptoms, diffuse interstitial infiltrates in the lungs on imaging studies, and eosinophilia exceeding 25% on bronchoalveolar lavage or pleural fluid smear. Smokers are primarily at increased risk for the disease. We present a case of venous thromboembolic disease (VTE) that developed in the course of AEP in a previously healthy male smoker. Complete remission of the disease was achieved with anticoagulation therapy combined with a low dose of steroids. Surprisingly, further diagnostics revealed the presence of thrombophilia: antithrombin (AT) deficiency and increased homocysteine level. According to our knowledge, this is the first case of VTE diagnosed in the course of AEP combined with thrombophilia. MDPI 2022-06-09 /pmc/articles/PMC9221981/ /pubmed/35741235 http://dx.doi.org/10.3390/diagnostics12061425 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jankowska, Ewa
Bartoszuk, Iwona
Lewandowska, Katarzyna
Dybowska, Małgorzata
Opoka, Lucyna
Tomkowski, Witold
Szturmowicz, Monika
Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations
title Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations
title_full Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations
title_fullStr Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations
title_full_unstemmed Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations
title_short Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations
title_sort acute eosinophilic pneumonia complicated with venous thromboembolic disease—diagnostic and therapeutic considerations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221981/
https://www.ncbi.nlm.nih.gov/pubmed/35741235
http://dx.doi.org/10.3390/diagnostics12061425
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