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Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020

Background: Each year, approximately two million adolescents and young adults in the world become infected with tuberculosis (TB). The problem is that the classification of the disease includes children in the age group 0–14 years and young adults aged 15 and over. The present study aims to analyze...

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Autores principales: Gabrovska, Natalia, Spasova, Albena, Galacheva, Anabela, Kostadinov, Dimitar, Yanev, Nikolay, Milanov, Vladimir, Gabrovski, Kaloyan, Velizarova, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221996/
https://www.ncbi.nlm.nih.gov/pubmed/35740721
http://dx.doi.org/10.3390/children9060785
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author Gabrovska, Natalia
Spasova, Albena
Galacheva, Anabela
Kostadinov, Dimitar
Yanev, Nikolay
Milanov, Vladimir
Gabrovski, Kaloyan
Velizarova, Svetlana
author_facet Gabrovska, Natalia
Spasova, Albena
Galacheva, Anabela
Kostadinov, Dimitar
Yanev, Nikolay
Milanov, Vladimir
Gabrovski, Kaloyan
Velizarova, Svetlana
author_sort Gabrovska, Natalia
collection PubMed
description Background: Each year, approximately two million adolescents and young adults in the world become infected with tuberculosis (TB). The problem is that the classification of the disease includes children in the age group 0–14 years and young adults aged 15 and over. The present study aims to analyze and compare the epidemiology and clinical presentation of TB in Bulgaria in the different age subgroups of childhood. Methods: A retrospective study was undertaken of the newly diagnosed children (n = 80) with TB treated onsite from January 2018 to December 2020 at the Multiprofile Hospital for Active Treatment of Pulmonary Diseases (“St. Sofia”). They were distributed into three age groups: aged 8–11 (prepuberty), aged 12–14 (younger adolescents), and aged above 15 (older adolescents). Results: A clear finding of the research indicated that adolescent children develop TB both as primary and secondary infections. In a large number of cases with the children under our care, we found enlarged intrathoracic lymph nodes as well as infiltrative changes in the lungs, i.e., we observed transitional forms. There were statistically significant differences between the age group >15 years old and each of the other two younger groups for diagnosis, the severity of intoxication, and BK spreading status. Conclusion: The course of tuberculosis in adolescence has its own specifics and differences between the three age groups in the current study.
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spelling pubmed-92219962022-06-24 Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020 Gabrovska, Natalia Spasova, Albena Galacheva, Anabela Kostadinov, Dimitar Yanev, Nikolay Milanov, Vladimir Gabrovski, Kaloyan Velizarova, Svetlana Children (Basel) Article Background: Each year, approximately two million adolescents and young adults in the world become infected with tuberculosis (TB). The problem is that the classification of the disease includes children in the age group 0–14 years and young adults aged 15 and over. The present study aims to analyze and compare the epidemiology and clinical presentation of TB in Bulgaria in the different age subgroups of childhood. Methods: A retrospective study was undertaken of the newly diagnosed children (n = 80) with TB treated onsite from January 2018 to December 2020 at the Multiprofile Hospital for Active Treatment of Pulmonary Diseases (“St. Sofia”). They were distributed into three age groups: aged 8–11 (prepuberty), aged 12–14 (younger adolescents), and aged above 15 (older adolescents). Results: A clear finding of the research indicated that adolescent children develop TB both as primary and secondary infections. In a large number of cases with the children under our care, we found enlarged intrathoracic lymph nodes as well as infiltrative changes in the lungs, i.e., we observed transitional forms. There were statistically significant differences between the age group >15 years old and each of the other two younger groups for diagnosis, the severity of intoxication, and BK spreading status. Conclusion: The course of tuberculosis in adolescence has its own specifics and differences between the three age groups in the current study. MDPI 2022-05-26 /pmc/articles/PMC9221996/ /pubmed/35740721 http://dx.doi.org/10.3390/children9060785 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gabrovska, Natalia
Spasova, Albena
Galacheva, Anabela
Kostadinov, Dimitar
Yanev, Nikolay
Milanov, Vladimir
Gabrovski, Kaloyan
Velizarova, Svetlana
Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020
title Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020
title_full Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020
title_fullStr Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020
title_full_unstemmed Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020
title_short Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018–2020
title_sort tuberculosis in adolescents in bulgaria for a three-year period: 2018–2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221996/
https://www.ncbi.nlm.nih.gov/pubmed/35740721
http://dx.doi.org/10.3390/children9060785
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