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T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study

Purpose: This study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding. Methods: The MRI-knee-scan...

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Autores principales: Schütz, Uwe, Martensen, Thomas, Kleiner, Sebastian, Dreyhaupt, Jens, Wegener, Martin, Wilke, Hans-Joachim, Beer, Meinrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222057/
https://www.ncbi.nlm.nih.gov/pubmed/35741201
http://dx.doi.org/10.3390/diagnostics12061391
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author Schütz, Uwe
Martensen, Thomas
Kleiner, Sebastian
Dreyhaupt, Jens
Wegener, Martin
Wilke, Hans-Joachim
Beer, Meinrad
author_facet Schütz, Uwe
Martensen, Thomas
Kleiner, Sebastian
Dreyhaupt, Jens
Wegener, Martin
Wilke, Hans-Joachim
Beer, Meinrad
author_sort Schütz, Uwe
collection PubMed
description Purpose: This study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding. Methods: The MRI-knee-scans (T2*-mapping) of four skiers using a conventional and a spring-loaded ski binding system, alternately, were acquired before and after 1 h/4 h of exposure to alpine skiing. Intrachondral T2* analysis on 60 defined regions of interest in the femorotibial knee joint (FTJ) was conducted. Intra- and interobserver variability and relative changes in the cartilage T2* signal and thickness were calculated. Results: A relevant decrease in the T2* time after 4 h of alpine skiing could be detected at the majority of measurement times. After overnight recovery, the T2* time increased above baseline. Although, the total T2* signal in the superficial cartilage layers was higher than that in the lower ones, no differences between the layers in the T2* changes could be detected. The central and posterior cartilage zones of the FTJ responded with a stronger T2* alteration than the anterior zones. Conclusions: For the first time, a quantitative MRI study setting could be established to detect early knee cartilage reaction due to alpine skiing. Relevant changes in the T2* time and thus in the intrachondral collagen microstructure and the free water content were observed.
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spelling pubmed-92220572022-06-24 T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study Schütz, Uwe Martensen, Thomas Kleiner, Sebastian Dreyhaupt, Jens Wegener, Martin Wilke, Hans-Joachim Beer, Meinrad Diagnostics (Basel) Article Purpose: This study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding. Methods: The MRI-knee-scans (T2*-mapping) of four skiers using a conventional and a spring-loaded ski binding system, alternately, were acquired before and after 1 h/4 h of exposure to alpine skiing. Intrachondral T2* analysis on 60 defined regions of interest in the femorotibial knee joint (FTJ) was conducted. Intra- and interobserver variability and relative changes in the cartilage T2* signal and thickness were calculated. Results: A relevant decrease in the T2* time after 4 h of alpine skiing could be detected at the majority of measurement times. After overnight recovery, the T2* time increased above baseline. Although, the total T2* signal in the superficial cartilage layers was higher than that in the lower ones, no differences between the layers in the T2* changes could be detected. The central and posterior cartilage zones of the FTJ responded with a stronger T2* alteration than the anterior zones. Conclusions: For the first time, a quantitative MRI study setting could be established to detect early knee cartilage reaction due to alpine skiing. Relevant changes in the T2* time and thus in the intrachondral collagen microstructure and the free water content were observed. MDPI 2022-06-04 /pmc/articles/PMC9222057/ /pubmed/35741201 http://dx.doi.org/10.3390/diagnostics12061391 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schütz, Uwe
Martensen, Thomas
Kleiner, Sebastian
Dreyhaupt, Jens
Wegener, Martin
Wilke, Hans-Joachim
Beer, Meinrad
T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
title T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
title_full T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
title_fullStr T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
title_full_unstemmed T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
title_short T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
title_sort t2*-mapping of knee cartilage in response to mechanical loading in alpine skiing: a feasibility study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222057/
https://www.ncbi.nlm.nih.gov/pubmed/35741201
http://dx.doi.org/10.3390/diagnostics12061391
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