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Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves

Background: Biomarkers were correlated with mortality in critically ill COVID-19 patients. No prediction tools exist for noncritically ill COVID-19 patients. We aimed to compare the independent prognostic value of inflammation and cardiac biomarkers for post-acute COVID-19 patients and the 30-day mo...

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Autores principales: Lionte, Catalina, Sorodoc, Victorita, Haliga, Raluca Ecaterina, Bologa, Cristina, Ceasovschih, Alexandr, Petris, Ovidiu Rusalim, Coman, Adorata Elena, Stoica, Alexandra, Sirbu, Oana, Puha, Gabriela, Constantin, Mihai, Dumitrescu, Gabriela, Gorciac, Victoria, Chelariu, Andrei-Costin, Catana, Andreea Nicoleta, Jaba, Elisabeta, Sorodoc, Laurentiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222082/
https://www.ncbi.nlm.nih.gov/pubmed/35741183
http://dx.doi.org/10.3390/diagnostics12061373
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author Lionte, Catalina
Sorodoc, Victorita
Haliga, Raluca Ecaterina
Bologa, Cristina
Ceasovschih, Alexandr
Petris, Ovidiu Rusalim
Coman, Adorata Elena
Stoica, Alexandra
Sirbu, Oana
Puha, Gabriela
Constantin, Mihai
Dumitrescu, Gabriela
Gorciac, Victoria
Chelariu, Andrei-Costin
Catana, Andreea Nicoleta
Jaba, Elisabeta
Sorodoc, Laurentiu
author_facet Lionte, Catalina
Sorodoc, Victorita
Haliga, Raluca Ecaterina
Bologa, Cristina
Ceasovschih, Alexandr
Petris, Ovidiu Rusalim
Coman, Adorata Elena
Stoica, Alexandra
Sirbu, Oana
Puha, Gabriela
Constantin, Mihai
Dumitrescu, Gabriela
Gorciac, Victoria
Chelariu, Andrei-Costin
Catana, Andreea Nicoleta
Jaba, Elisabeta
Sorodoc, Laurentiu
author_sort Lionte, Catalina
collection PubMed
description Background: Biomarkers were correlated with mortality in critically ill COVID-19 patients. No prediction tools exist for noncritically ill COVID-19 patients. We aimed to compare the independent prognostic value of inflammation and cardiac biomarkers for post-acute COVID-19 patients and the 30-day mortality rate in noncritically ill COVID-19 patients, as well as the relation with the virus variant involved. Methods: This observational cohort study was conducted at an emergency clinical hospital between 1 October 2020 and 31 December 2021. We included consecutive patients with biomarkers determined within 24 h of presentation, followed up at least 30 days postdischarge. Results: Post-acute COVID-19 was diagnosed in 20.3% of the cases and the all-cause 30-day mortality rate was 35.1% among 978 patients infected with variants of concern. Neutrophil-to-lymphocyte ratio (1.06 [95%CI, 1.01–1.11], p = 0.015) and NT-pro BNP were correlated with 30-daymortality, while the monocyte-to-lymphocyte ratio (2.77 [95%CI, 1.10–6.94], p = 0.03) and NT-pro BNP (1.68 [95%CI, 1.00–2.84], p = 0.05) were correlated with post-acute COVID-19. High-sensitivity to troponin was associated with 30-day mortality (1.55 [95%CI, 1.00–2.42], p = 0.05). A Cox proportional-hazards model confirmed that NT-pro BNP was independently associated with mortality. NT-pro BNP remained independently associated with 30-day mortality during follow-up (1.29 [95%CI, 1.07–1.56], p = 0.007) after adjustment for confounders. Conclusion: Inflammation and cardiac biomarkers, determined upon admission and predischarge, in a cohort of hospitalized noncritically ill COVID-19 patients throughout successive pandemic waves, showed a predictive value for post-acute COVID-19 and 30-day mortality.
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spelling pubmed-92220822022-06-24 Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves Lionte, Catalina Sorodoc, Victorita Haliga, Raluca Ecaterina Bologa, Cristina Ceasovschih, Alexandr Petris, Ovidiu Rusalim Coman, Adorata Elena Stoica, Alexandra Sirbu, Oana Puha, Gabriela Constantin, Mihai Dumitrescu, Gabriela Gorciac, Victoria Chelariu, Andrei-Costin Catana, Andreea Nicoleta Jaba, Elisabeta Sorodoc, Laurentiu Diagnostics (Basel) Article Background: Biomarkers were correlated with mortality in critically ill COVID-19 patients. No prediction tools exist for noncritically ill COVID-19 patients. We aimed to compare the independent prognostic value of inflammation and cardiac biomarkers for post-acute COVID-19 patients and the 30-day mortality rate in noncritically ill COVID-19 patients, as well as the relation with the virus variant involved. Methods: This observational cohort study was conducted at an emergency clinical hospital between 1 October 2020 and 31 December 2021. We included consecutive patients with biomarkers determined within 24 h of presentation, followed up at least 30 days postdischarge. Results: Post-acute COVID-19 was diagnosed in 20.3% of the cases and the all-cause 30-day mortality rate was 35.1% among 978 patients infected with variants of concern. Neutrophil-to-lymphocyte ratio (1.06 [95%CI, 1.01–1.11], p = 0.015) and NT-pro BNP were correlated with 30-daymortality, while the monocyte-to-lymphocyte ratio (2.77 [95%CI, 1.10–6.94], p = 0.03) and NT-pro BNP (1.68 [95%CI, 1.00–2.84], p = 0.05) were correlated with post-acute COVID-19. High-sensitivity to troponin was associated with 30-day mortality (1.55 [95%CI, 1.00–2.42], p = 0.05). A Cox proportional-hazards model confirmed that NT-pro BNP was independently associated with mortality. NT-pro BNP remained independently associated with 30-day mortality during follow-up (1.29 [95%CI, 1.07–1.56], p = 0.007) after adjustment for confounders. Conclusion: Inflammation and cardiac biomarkers, determined upon admission and predischarge, in a cohort of hospitalized noncritically ill COVID-19 patients throughout successive pandemic waves, showed a predictive value for post-acute COVID-19 and 30-day mortality. MDPI 2022-06-02 /pmc/articles/PMC9222082/ /pubmed/35741183 http://dx.doi.org/10.3390/diagnostics12061373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lionte, Catalina
Sorodoc, Victorita
Haliga, Raluca Ecaterina
Bologa, Cristina
Ceasovschih, Alexandr
Petris, Ovidiu Rusalim
Coman, Adorata Elena
Stoica, Alexandra
Sirbu, Oana
Puha, Gabriela
Constantin, Mihai
Dumitrescu, Gabriela
Gorciac, Victoria
Chelariu, Andrei-Costin
Catana, Andreea Nicoleta
Jaba, Elisabeta
Sorodoc, Laurentiu
Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
title Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
title_full Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
title_fullStr Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
title_full_unstemmed Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
title_short Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
title_sort inflammatory and cardiac biomarkers in relation with post-acute covid-19 and mortality: what we know after successive pandemic waves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222082/
https://www.ncbi.nlm.nih.gov/pubmed/35741183
http://dx.doi.org/10.3390/diagnostics12061373
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