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Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness

Background: Children with non-syndromic hereditary sensorineural hearing loss (SNHL) provide an opportunity to explore the impact of hearing on brain development. Objective: This study investigates volumetric differences of key hearing-related structures in children with gap junction protein beta 2...

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Autores principales: Wagner, Matthias W., Cushing, Sharon L., Tshuma, Makabongwe, Gordon, Karen A., Ertl-Wagner, Birgit B., Vidarsson, Logi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222099/
https://www.ncbi.nlm.nih.gov/pubmed/35740737
http://dx.doi.org/10.3390/children9060800
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author Wagner, Matthias W.
Cushing, Sharon L.
Tshuma, Makabongwe
Gordon, Karen A.
Ertl-Wagner, Birgit B.
Vidarsson, Logi
author_facet Wagner, Matthias W.
Cushing, Sharon L.
Tshuma, Makabongwe
Gordon, Karen A.
Ertl-Wagner, Birgit B.
Vidarsson, Logi
author_sort Wagner, Matthias W.
collection PubMed
description Background: Children with non-syndromic hereditary sensorineural hearing loss (SNHL) provide an opportunity to explore the impact of hearing on brain development. Objective: This study investigates volumetric differences of key hearing-related structures in children with gap junction protein beta 2 GJB2-related SNHL compared to controls. Materials and methods: Ninety-four children with SNHL (n = 15) or normal hearing (n = 79) were studied using automated volumetric segmentation. Heschl’s gyrus (HG), anterior HG (aHG), planum temporale (PT), medial geniculate nucleus (MGN), and nucleus accumbens (NA) were analyzed relative to total brain volume (TBV) at two different age groups: (1) 7–12 months and (2) 13 months–18 years. Two-sided t-tests were used to evaluate differences between groups. Differences were considered significant if p < 0.007. Results: Significantly smaller aHG-to-TBV ratios were found in 13-month-to-18-year-old patients (p < 0.0055). HG-, PT-, MGN-, and NA-to-TBV ratios were smaller in the same age group, without reaching a significant level. Conversely, HG- and NA-to-TBV were larger in the younger age group. No significant differences were found between the groups for age and TBV. Conclusions: In this exploratory volumetric analysis of key hearing-related structures, we observed age-related changes in volume in children with GJB2-related SNHL.
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spelling pubmed-92220992022-06-24 Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness Wagner, Matthias W. Cushing, Sharon L. Tshuma, Makabongwe Gordon, Karen A. Ertl-Wagner, Birgit B. Vidarsson, Logi Children (Basel) Article Background: Children with non-syndromic hereditary sensorineural hearing loss (SNHL) provide an opportunity to explore the impact of hearing on brain development. Objective: This study investigates volumetric differences of key hearing-related structures in children with gap junction protein beta 2 GJB2-related SNHL compared to controls. Materials and methods: Ninety-four children with SNHL (n = 15) or normal hearing (n = 79) were studied using automated volumetric segmentation. Heschl’s gyrus (HG), anterior HG (aHG), planum temporale (PT), medial geniculate nucleus (MGN), and nucleus accumbens (NA) were analyzed relative to total brain volume (TBV) at two different age groups: (1) 7–12 months and (2) 13 months–18 years. Two-sided t-tests were used to evaluate differences between groups. Differences were considered significant if p < 0.007. Results: Significantly smaller aHG-to-TBV ratios were found in 13-month-to-18-year-old patients (p < 0.0055). HG-, PT-, MGN-, and NA-to-TBV ratios were smaller in the same age group, without reaching a significant level. Conversely, HG- and NA-to-TBV were larger in the younger age group. No significant differences were found between the groups for age and TBV. Conclusions: In this exploratory volumetric analysis of key hearing-related structures, we observed age-related changes in volume in children with GJB2-related SNHL. MDPI 2022-05-30 /pmc/articles/PMC9222099/ /pubmed/35740737 http://dx.doi.org/10.3390/children9060800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wagner, Matthias W.
Cushing, Sharon L.
Tshuma, Makabongwe
Gordon, Karen A.
Ertl-Wagner, Birgit B.
Vidarsson, Logi
Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
title Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
title_full Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
title_fullStr Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
title_full_unstemmed Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
title_short Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
title_sort volumetric analysis of hearing-related structures of brain in children with gjb2-related congenital deafness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222099/
https://www.ncbi.nlm.nih.gov/pubmed/35740737
http://dx.doi.org/10.3390/children9060800
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