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Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome

The management of patients with peripheral artery disease (PAD) is integrative and multidisciplinary, in which cardiac rehabilitation (CR) plays a prognostic role in terms of functional status, quality of life, and long-term impact on morbidity and mortality. We conducted a prospective cohort study...

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Autores principales: Anghel, Razvan, Adam, Cristina Andreea, Mitu, Ovidiu, Marcu, Dragos Traian Marius, Onofrei, Viviana, Roca, Mihai, Costache, Alexandru Dan, Miftode, Radu Stefan, Tinica, Grigore, Mitu, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222166/
https://www.ncbi.nlm.nih.gov/pubmed/35741309
http://dx.doi.org/10.3390/diagnostics12061500
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author Anghel, Razvan
Adam, Cristina Andreea
Mitu, Ovidiu
Marcu, Dragos Traian Marius
Onofrei, Viviana
Roca, Mihai
Costache, Alexandru Dan
Miftode, Radu Stefan
Tinica, Grigore
Mitu, Florin
author_facet Anghel, Razvan
Adam, Cristina Andreea
Mitu, Ovidiu
Marcu, Dragos Traian Marius
Onofrei, Viviana
Roca, Mihai
Costache, Alexandru Dan
Miftode, Radu Stefan
Tinica, Grigore
Mitu, Florin
author_sort Anghel, Razvan
collection PubMed
description The management of patients with peripheral artery disease (PAD) is integrative and multidisciplinary, in which cardiac rehabilitation (CR) plays a prognostic role in terms of functional status, quality of life, and long-term impact on morbidity and mortality. We conducted a prospective cohort study on 97 patients with PAD admitted to a single tertiary referral center. Based on a prognostic index developed to stratify long-term mortality risk in PAD patients, we divided the cohort into two groups: low and low-intermediate risk group (45 cases) and high-intermediate and high risk group (52 cases). We analyzed demographics, clinical parameters, and paraclinical parameters in the two groups, as well as factors associated with cardiological reassessment prior to the established deadline of 6 months. Obesity (p = 0.048), renal dysfunction (p < 0.001), dyslipidemia (p < 0.001), tobacco use (p = 0.048), and diabetes mellitus (p < 0.001) are comorbidities with long-term prognostic value. Low-density lipoprotein cholesterol (p = 0.002), triglycerides (p = 0.032), fasting glucose (p = 0.011), peak oxygen uptake (p = 0.005), pain-free walking distance (p = 0.011), maximum walking time (p < 0.001), and maximum walking distance (p = 0.002) influence the outcome of PAD patients by being factors associated with clinical improvement at the 6-month follow-up. PAD patients benefit from enrollment in CR programs, improvement of clinical signs, lipid and carbohydrate profile, and weight loss and maintenance of blood pressure profile within normal limits, as well as increased exercise capacity being therapeutic targets.
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spelling pubmed-92221662022-06-24 Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome Anghel, Razvan Adam, Cristina Andreea Mitu, Ovidiu Marcu, Dragos Traian Marius Onofrei, Viviana Roca, Mihai Costache, Alexandru Dan Miftode, Radu Stefan Tinica, Grigore Mitu, Florin Diagnostics (Basel) Article The management of patients with peripheral artery disease (PAD) is integrative and multidisciplinary, in which cardiac rehabilitation (CR) plays a prognostic role in terms of functional status, quality of life, and long-term impact on morbidity and mortality. We conducted a prospective cohort study on 97 patients with PAD admitted to a single tertiary referral center. Based on a prognostic index developed to stratify long-term mortality risk in PAD patients, we divided the cohort into two groups: low and low-intermediate risk group (45 cases) and high-intermediate and high risk group (52 cases). We analyzed demographics, clinical parameters, and paraclinical parameters in the two groups, as well as factors associated with cardiological reassessment prior to the established deadline of 6 months. Obesity (p = 0.048), renal dysfunction (p < 0.001), dyslipidemia (p < 0.001), tobacco use (p = 0.048), and diabetes mellitus (p < 0.001) are comorbidities with long-term prognostic value. Low-density lipoprotein cholesterol (p = 0.002), triglycerides (p = 0.032), fasting glucose (p = 0.011), peak oxygen uptake (p = 0.005), pain-free walking distance (p = 0.011), maximum walking time (p < 0.001), and maximum walking distance (p = 0.002) influence the outcome of PAD patients by being factors associated with clinical improvement at the 6-month follow-up. PAD patients benefit from enrollment in CR programs, improvement of clinical signs, lipid and carbohydrate profile, and weight loss and maintenance of blood pressure profile within normal limits, as well as increased exercise capacity being therapeutic targets. MDPI 2022-06-20 /pmc/articles/PMC9222166/ /pubmed/35741309 http://dx.doi.org/10.3390/diagnostics12061500 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anghel, Razvan
Adam, Cristina Andreea
Mitu, Ovidiu
Marcu, Dragos Traian Marius
Onofrei, Viviana
Roca, Mihai
Costache, Alexandru Dan
Miftode, Radu Stefan
Tinica, Grigore
Mitu, Florin
Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome
title Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome
title_full Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome
title_fullStr Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome
title_full_unstemmed Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome
title_short Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome
title_sort cardiac rehabilitation and mortality risk reduction in peripheral artery disease at 6-month outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222166/
https://www.ncbi.nlm.nih.gov/pubmed/35741309
http://dx.doi.org/10.3390/diagnostics12061500
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