Cargando…
The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study
Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregn...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222210/ https://www.ncbi.nlm.nih.gov/pubmed/35741142 http://dx.doi.org/10.3390/diagnostics12061334 |
_version_ | 1784732818360762368 |
---|---|
author | Li, Huanrong Lyu, Meilu Zhao, Ruqian Zang, Yuqin Huang, Pengzhu Li, Jie Yan, Ye Wang, Yingmei Li, Zengyan Han, Cha Xue, Fengxia |
author_facet | Li, Huanrong Lyu, Meilu Zhao, Ruqian Zang, Yuqin Huang, Pengzhu Li, Jie Yan, Ye Wang, Yingmei Li, Zengyan Han, Cha Xue, Fengxia |
author_sort | Li, Huanrong |
collection | PubMed |
description | Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s t-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187–2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week < 34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (p < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal–neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART. |
format | Online Article Text |
id | pubmed-9222210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92222102022-06-24 The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study Li, Huanrong Lyu, Meilu Zhao, Ruqian Zang, Yuqin Huang, Pengzhu Li, Jie Yan, Ye Wang, Yingmei Li, Zengyan Han, Cha Xue, Fengxia Diagnostics (Basel) Article Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s t-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187–2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week < 34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (p < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal–neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART. MDPI 2022-05-27 /pmc/articles/PMC9222210/ /pubmed/35741142 http://dx.doi.org/10.3390/diagnostics12061334 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Huanrong Lyu, Meilu Zhao, Ruqian Zang, Yuqin Huang, Pengzhu Li, Jie Yan, Ye Wang, Yingmei Li, Zengyan Han, Cha Xue, Fengxia The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
title | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
title_full | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
title_fullStr | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
title_full_unstemmed | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
title_short | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
title_sort | maternal–neonatal outcomes of twin pregnancies with preeclampsia and their association with assisted reproductive technology: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222210/ https://www.ncbi.nlm.nih.gov/pubmed/35741142 http://dx.doi.org/10.3390/diagnostics12061334 |
work_keys_str_mv | AT lihuanrong thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lyumeilu thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT zhaoruqian thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT zangyuqin thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT huangpengzhu thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lijie thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT yanye thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT wangyingmei thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lizengyan thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT hancha thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT xuefengxia thematernalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lihuanrong maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lyumeilu maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT zhaoruqian maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT zangyuqin maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT huangpengzhu maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lijie maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT yanye maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT wangyingmei maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT lizengyan maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT hancha maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy AT xuefengxia maternalneonataloutcomesoftwinpregnancieswithpreeclampsiaandtheirassociationwithassistedreproductivetechnologyaretrospectivestudy |