Cargando…

Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies

Ground ivy (Glechoma hederacea L.) has been known as a medicinal plant in folk medicine for generations and, as a member of the Lamiaceae family, is characterized with a high content of rosmarinic acid. The aim of the present study was to formulate delivery systems containing bioactive compounds fro...

Descripción completa

Detalles Bibliográficos
Autores principales: Šeremet, Danijela, Štefančić, Martina, Petrović, Predrag, Kuzmić, Sunčica, Doroci, Shefkije, Mandura Jarić, Ana, Vojvodić Cebin, Aleksandra, Pjanović, Rada, Komes, Draženka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222263/
https://www.ncbi.nlm.nih.gov/pubmed/35742016
http://dx.doi.org/10.3390/foods11121816
_version_ 1784732831176458240
author Šeremet, Danijela
Štefančić, Martina
Petrović, Predrag
Kuzmić, Sunčica
Doroci, Shefkije
Mandura Jarić, Ana
Vojvodić Cebin, Aleksandra
Pjanović, Rada
Komes, Draženka
author_facet Šeremet, Danijela
Štefančić, Martina
Petrović, Predrag
Kuzmić, Sunčica
Doroci, Shefkije
Mandura Jarić, Ana
Vojvodić Cebin, Aleksandra
Pjanović, Rada
Komes, Draženka
author_sort Šeremet, Danijela
collection PubMed
description Ground ivy (Glechoma hederacea L.) has been known as a medicinal plant in folk medicine for generations and, as a member of the Lamiaceae family, is characterized with a high content of rosmarinic acid. The aim of the present study was to formulate delivery systems containing bioactive compounds from ground ivy in encapsulated form and incorporated into candies. Liposomes were examined as the encapsulation systems that were additionally coated with an alginate–plant protein gel to reduce leakage of the incorporated material. Bioactive characterization of the ground ivy extract showed a high content of total phenolics (1186.20 mg GAE/L) and rosmarinic acid (46.04 mg/L). The formulation of liposomes with the high encapsulation efficiency of rosmarinic acid (97.64%), with at least a double bilayer and with polydisperse particle size distribution was achieved. Alginate microparticles reinforced with rice proteins provided the highest encapsulation efficiency for rosmarinic acid (78.16%) and were therefore used for the successful coating of liposomes, as confirmed by FT-IR analysis. Coating liposomes with alginate–rice protein gel provided prolonged controlled release of rosmarinic acid during simulated gastro-intestinal digestion, and the same was noted when they were incorporated into candies.
format Online
Article
Text
id pubmed-9222263
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92222632022-06-24 Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies Šeremet, Danijela Štefančić, Martina Petrović, Predrag Kuzmić, Sunčica Doroci, Shefkije Mandura Jarić, Ana Vojvodić Cebin, Aleksandra Pjanović, Rada Komes, Draženka Foods Article Ground ivy (Glechoma hederacea L.) has been known as a medicinal plant in folk medicine for generations and, as a member of the Lamiaceae family, is characterized with a high content of rosmarinic acid. The aim of the present study was to formulate delivery systems containing bioactive compounds from ground ivy in encapsulated form and incorporated into candies. Liposomes were examined as the encapsulation systems that were additionally coated with an alginate–plant protein gel to reduce leakage of the incorporated material. Bioactive characterization of the ground ivy extract showed a high content of total phenolics (1186.20 mg GAE/L) and rosmarinic acid (46.04 mg/L). The formulation of liposomes with the high encapsulation efficiency of rosmarinic acid (97.64%), with at least a double bilayer and with polydisperse particle size distribution was achieved. Alginate microparticles reinforced with rice proteins provided the highest encapsulation efficiency for rosmarinic acid (78.16%) and were therefore used for the successful coating of liposomes, as confirmed by FT-IR analysis. Coating liposomes with alginate–rice protein gel provided prolonged controlled release of rosmarinic acid during simulated gastro-intestinal digestion, and the same was noted when they were incorporated into candies. MDPI 2022-06-20 /pmc/articles/PMC9222263/ /pubmed/35742016 http://dx.doi.org/10.3390/foods11121816 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Šeremet, Danijela
Štefančić, Martina
Petrović, Predrag
Kuzmić, Sunčica
Doroci, Shefkije
Mandura Jarić, Ana
Vojvodić Cebin, Aleksandra
Pjanović, Rada
Komes, Draženka
Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies
title Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies
title_full Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies
title_fullStr Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies
title_full_unstemmed Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies
title_short Development, Characterization and Incorporation of Alginate-Plant Protein Covered Liposomes Containing Ground Ivy (Glechoma hederacea L.) Extract into Candies
title_sort development, characterization and incorporation of alginate-plant protein covered liposomes containing ground ivy (glechoma hederacea l.) extract into candies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222263/
https://www.ncbi.nlm.nih.gov/pubmed/35742016
http://dx.doi.org/10.3390/foods11121816
work_keys_str_mv AT seremetdanijela developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT stefancicmartina developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT petrovicpredrag developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT kuzmicsuncica developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT dorocishefkije developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT mandurajaricana developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT vojvodiccebinaleksandra developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT pjanovicrada developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies
AT komesdrazenka developmentcharacterizationandincorporationofalginateplantproteincoveredliposomescontaininggroundivyglechomahederacealextractintocandies