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Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved

Helicobacter pylori is a bacterium associated with various gastrointestinal diseases of high worldwide prevalence. Since probiotics are an emerging alternative to managing infection by this pathogenic bacterium, the present work evaluated, in a randomized double-blind study controlled by a placebo,...

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Autores principales: Parra-Sepúlveda, Cristian, Sánchez-Alonzo, Kimberly, Olivares-Muñoz, Joaquín, Gutiérrez-Zamorano, Cristian, Smith, Carlos T., Carvajal, Romina I., Sáez-Carrillo, Katia, González, Carlos, García-Cancino, Apolinaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222482/
https://www.ncbi.nlm.nih.gov/pubmed/35741866
http://dx.doi.org/10.3390/foods11121668
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author Parra-Sepúlveda, Cristian
Sánchez-Alonzo, Kimberly
Olivares-Muñoz, Joaquín
Gutiérrez-Zamorano, Cristian
Smith, Carlos T.
Carvajal, Romina I.
Sáez-Carrillo, Katia
González, Carlos
García-Cancino, Apolinaria
author_facet Parra-Sepúlveda, Cristian
Sánchez-Alonzo, Kimberly
Olivares-Muñoz, Joaquín
Gutiérrez-Zamorano, Cristian
Smith, Carlos T.
Carvajal, Romina I.
Sáez-Carrillo, Katia
González, Carlos
García-Cancino, Apolinaria
author_sort Parra-Sepúlveda, Cristian
collection PubMed
description Helicobacter pylori is a bacterium associated with various gastrointestinal diseases of high worldwide prevalence. Since probiotics are an emerging alternative to managing infection by this pathogenic bacterium, the present work evaluated, in a randomized double-blind study controlled by a placebo, if consuming Limosilactobacillus fermentum UCO-979C prevents H. pylori infection in humans. Participants consumed either L. fermentum UCO-979C-supplemented gelatin (67 participants) or placebo-supplemented gelatin (64 participants) once a day, five days per week for 12 weeks. H. pylori infection in the participants was controlled before and after the intervention detecting H. pylori antigens in stools. Regarding H. pylori-infected participants before the study, 100% remained infected at the end of the study in the placebo group, while 96.7% of those receiving the probiotic remained infected after the intervention. Most importantly, of the non-infected participants, 34.2% became infected and 65.8% remained non-infected in the placebo group, while 2.7% became infected and 97.3% remained as non-infected individuals in the intervened group. Therefore, consuming the L. fermentum UCO-979C strain significantly reduced H. pylori infection, demonstrating a 92.6% efficacy in avoiding infection by this pathogen in non-infected individuals; thus, this probiotic is an excellent candidate to prevent H. pylori infections in non-infected individuals.
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spelling pubmed-92224822022-06-24 Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved Parra-Sepúlveda, Cristian Sánchez-Alonzo, Kimberly Olivares-Muñoz, Joaquín Gutiérrez-Zamorano, Cristian Smith, Carlos T. Carvajal, Romina I. Sáez-Carrillo, Katia González, Carlos García-Cancino, Apolinaria Foods Article Helicobacter pylori is a bacterium associated with various gastrointestinal diseases of high worldwide prevalence. Since probiotics are an emerging alternative to managing infection by this pathogenic bacterium, the present work evaluated, in a randomized double-blind study controlled by a placebo, if consuming Limosilactobacillus fermentum UCO-979C prevents H. pylori infection in humans. Participants consumed either L. fermentum UCO-979C-supplemented gelatin (67 participants) or placebo-supplemented gelatin (64 participants) once a day, five days per week for 12 weeks. H. pylori infection in the participants was controlled before and after the intervention detecting H. pylori antigens in stools. Regarding H. pylori-infected participants before the study, 100% remained infected at the end of the study in the placebo group, while 96.7% of those receiving the probiotic remained infected after the intervention. Most importantly, of the non-infected participants, 34.2% became infected and 65.8% remained non-infected in the placebo group, while 2.7% became infected and 97.3% remained as non-infected individuals in the intervened group. Therefore, consuming the L. fermentum UCO-979C strain significantly reduced H. pylori infection, demonstrating a 92.6% efficacy in avoiding infection by this pathogen in non-infected individuals; thus, this probiotic is an excellent candidate to prevent H. pylori infections in non-infected individuals. MDPI 2022-06-07 /pmc/articles/PMC9222482/ /pubmed/35741866 http://dx.doi.org/10.3390/foods11121668 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parra-Sepúlveda, Cristian
Sánchez-Alonzo, Kimberly
Olivares-Muñoz, Joaquín
Gutiérrez-Zamorano, Cristian
Smith, Carlos T.
Carvajal, Romina I.
Sáez-Carrillo, Katia
González, Carlos
García-Cancino, Apolinaria
Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved
title Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved
title_full Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved
title_fullStr Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved
title_full_unstemmed Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved
title_short Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved
title_sort consumption of a gelatin supplemented with the probiotic strain limosilactobacillus fermentum uco-979c prevents helicobacter pylori infection in a young adult population achieved
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222482/
https://www.ncbi.nlm.nih.gov/pubmed/35741866
http://dx.doi.org/10.3390/foods11121668
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