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Recent Studies on Hydrogels Based on H(2)O(2)-Responsive Moieties: Mechanism, Preparation and Application

H(2)O(2) is essential for cellular processes and plays a vital role in the regulation of cell signaling pathways, which can be viewed as a warning signal for many kinds of disease including cancer, cardiovascular disease, reproductive abnormalities, diabetes, and renal failure. A H(2)O(2)-responsive...

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Detalles Bibliográficos
Autores principales: Song, Weihua, You, Jipeng, Zhang, Yuangong, Yang, Qi, Jiao, Jin, Zhang, Hailei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222492/
https://www.ncbi.nlm.nih.gov/pubmed/35735705
http://dx.doi.org/10.3390/gels8060361
Descripción
Sumario:H(2)O(2) is essential for cellular processes and plays a vital role in the regulation of cell signaling pathways, which can be viewed as a warning signal for many kinds of disease including cancer, cardiovascular disease, reproductive abnormalities, diabetes, and renal failure. A H(2)O(2)-responsive hydrogel (H(2)O(2)-Gel) is a promising candidate for biomedical applications because of its good biocompatibility, similarity to soft biological tissues, ease of preparation, and its ability to respond to H(2)O(2). In this study, the H(2)O(2)-responsive moieties used to fabricate H(2)O(2)-Gels were reviewed, including thioethers, disulfide bonds, selenides, diselenium bonds, diketones, boronic, and others. Next, the preparation method of H(2)O(2)-Gel was divided into two major categories according to their reaction mechanisms: either self-crosslinking or mechanisms entailing the addition of difunctional crosslinkers. Last, the applications of H(2)O(2)-Gels were emphasized, which have been viewed as desirable candidates in the fields of drug delivery, the detection of H(2)O(2), glucose-responsive systems, ROS scavengers, tissue engineering, and cell-encapsulation.