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The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review

According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we asses...

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Detalles Bibliográficos
Autores principales: Khogeer, Asim A., AboMansour, Iman S., Mohammed, Dia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222497/
https://www.ncbi.nlm.nih.gov/pubmed/35735472
http://dx.doi.org/10.3390/epigenomes6020015
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author Khogeer, Asim A.
AboMansour, Iman S.
Mohammed, Dia A.
author_facet Khogeer, Asim A.
AboMansour, Iman S.
Mohammed, Dia A.
author_sort Khogeer, Asim A.
collection PubMed
description According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we assess several reviews with regard to their quality of evidence and provide a brief outline of the presumed mechanisms of the genetic, epigenetic, and environmental risk factors of ASD. We also review some of the critical literature, which supports the basis of each factor in the underlying and specific risk patterns of ASD. Finally, we consider some of the implications of recent research regarding potential molecular targets for future investigations.
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spelling pubmed-92224972022-06-24 The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review Khogeer, Asim A. AboMansour, Iman S. Mohammed, Dia A. Epigenomes Review According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we assess several reviews with regard to their quality of evidence and provide a brief outline of the presumed mechanisms of the genetic, epigenetic, and environmental risk factors of ASD. We also review some of the critical literature, which supports the basis of each factor in the underlying and specific risk patterns of ASD. Finally, we consider some of the implications of recent research regarding potential molecular targets for future investigations. MDPI 2022-06-19 /pmc/articles/PMC9222497/ /pubmed/35735472 http://dx.doi.org/10.3390/epigenomes6020015 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khogeer, Asim A.
AboMansour, Iman S.
Mohammed, Dia A.
The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
title The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
title_full The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
title_fullStr The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
title_full_unstemmed The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
title_short The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
title_sort role of genetics, epigenetics, and the environment in asd: a mini review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222497/
https://www.ncbi.nlm.nih.gov/pubmed/35735472
http://dx.doi.org/10.3390/epigenomes6020015
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