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Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex
It is considered that brain ischemia can be causative connected to Alzheimer’s disease. In the CA1 and CA3 regions of the hippocampus and temporal cortex, genes related to Alzheimer’s disease, such as the amyloid protein precursor (APP), β-secretase (BACE1), presenilin 1 (PSEN1) and 2 (PSEN2), are d...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222545/ https://www.ncbi.nlm.nih.gov/pubmed/35741821 http://dx.doi.org/10.3390/genes13061059 |
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author | Pluta, Ryszard |
author_facet | Pluta, Ryszard |
author_sort | Pluta, Ryszard |
collection | PubMed |
description | It is considered that brain ischemia can be causative connected to Alzheimer’s disease. In the CA1 and CA3 regions of the hippocampus and temporal cortex, genes related to Alzheimer’s disease, such as the amyloid protein precursor (APP), β-secretase (BACE1), presenilin 1 (PSEN1) and 2 (PSEN2), are deregulated by ischemia. The pattern of change in the CA1 area of the hippocampus covers all genes tested, and the changes occur at all post-ischemic times. In contrast, the pattern of gene changes in the CA3 subfield is much less intense, does not occur at all post-ischemic times, and is delayed in time post-ischemia relative to the CA1 field. Conversely, the pattern of gene alterations in the temporal cortex appears immediately after ischemia, and does not occur at all post-ischemic times and does not affect all genes. Evidence therefore suggests that various forms of dysregulation of the APP, BACE1 and PSEN1 and PSEN2 genes are associated with individual neuronal cell responses in the CA1 and CA3 areas of the hippocampus and temporal cortex with reversible cerebral ischemia. Scientific data indicate that an ischemic episode of the brain is a trigger of amyloidogenic processes. From the information provided, it appears that post-ischemic brain injury additionally activates neuronal death in the hippocampus and temporal cortex in an amyloid-dependent manner. |
format | Online Article Text |
id | pubmed-9222545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92225452022-06-24 Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex Pluta, Ryszard Genes (Basel) Review It is considered that brain ischemia can be causative connected to Alzheimer’s disease. In the CA1 and CA3 regions of the hippocampus and temporal cortex, genes related to Alzheimer’s disease, such as the amyloid protein precursor (APP), β-secretase (BACE1), presenilin 1 (PSEN1) and 2 (PSEN2), are deregulated by ischemia. The pattern of change in the CA1 area of the hippocampus covers all genes tested, and the changes occur at all post-ischemic times. In contrast, the pattern of gene changes in the CA3 subfield is much less intense, does not occur at all post-ischemic times, and is delayed in time post-ischemia relative to the CA1 field. Conversely, the pattern of gene alterations in the temporal cortex appears immediately after ischemia, and does not occur at all post-ischemic times and does not affect all genes. Evidence therefore suggests that various forms of dysregulation of the APP, BACE1 and PSEN1 and PSEN2 genes are associated with individual neuronal cell responses in the CA1 and CA3 areas of the hippocampus and temporal cortex with reversible cerebral ischemia. Scientific data indicate that an ischemic episode of the brain is a trigger of amyloidogenic processes. From the information provided, it appears that post-ischemic brain injury additionally activates neuronal death in the hippocampus and temporal cortex in an amyloid-dependent manner. MDPI 2022-06-14 /pmc/articles/PMC9222545/ /pubmed/35741821 http://dx.doi.org/10.3390/genes13061059 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pluta, Ryszard Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
title | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
title_full | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
title_fullStr | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
title_full_unstemmed | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
title_short | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
title_sort | alzheimer’s disease connected genes in the post-ischemic hippocampus and temporal cortex |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222545/ https://www.ncbi.nlm.nih.gov/pubmed/35741821 http://dx.doi.org/10.3390/genes13061059 |
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