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Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222548/ https://www.ncbi.nlm.nih.gov/pubmed/35735733 http://dx.doi.org/10.3390/gels8060389 |
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author | Chang, Shuai Wang, Shaobo Liu, Zhongjun Wang, Xing |
author_facet | Chang, Shuai Wang, Shaobo Liu, Zhongjun Wang, Xing |
author_sort | Chang, Shuai |
collection | PubMed |
description | Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and degradability. Stimulus-responsive hydrogels, as a new type of smart biomaterial, have more advantages in sensing external physical (light, temperature, pressure, electric field, magnetic field, etc.), chemical (pH, redox reaction, ions, etc.), biochemical (glucose, enzymes, etc.) and other different stimuli. They can respond to stimuli such as the characteristics of the 3D shape and solid–liquid phase state, and exhibit special properties (injection ability, self-repair, shape memory, etc.), thus becoming an ideal material to provide cell adhesion, proliferation, and differentiation, and achieve precise bone defect repair. This review is focused on the classification, design concepts, and research progress of stimulus-responsive hydrogels based on different types of external environmental stimuli, aiming at introducing new ideas and methods for repairing complex bone defects. |
format | Online Article Text |
id | pubmed-9222548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92225482022-06-24 Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering Chang, Shuai Wang, Shaobo Liu, Zhongjun Wang, Xing Gels Review Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and degradability. Stimulus-responsive hydrogels, as a new type of smart biomaterial, have more advantages in sensing external physical (light, temperature, pressure, electric field, magnetic field, etc.), chemical (pH, redox reaction, ions, etc.), biochemical (glucose, enzymes, etc.) and other different stimuli. They can respond to stimuli such as the characteristics of the 3D shape and solid–liquid phase state, and exhibit special properties (injection ability, self-repair, shape memory, etc.), thus becoming an ideal material to provide cell adhesion, proliferation, and differentiation, and achieve precise bone defect repair. This review is focused on the classification, design concepts, and research progress of stimulus-responsive hydrogels based on different types of external environmental stimuli, aiming at introducing new ideas and methods for repairing complex bone defects. MDPI 2022-06-20 /pmc/articles/PMC9222548/ /pubmed/35735733 http://dx.doi.org/10.3390/gels8060389 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chang, Shuai Wang, Shaobo Liu, Zhongjun Wang, Xing Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering |
title | Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering |
title_full | Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering |
title_fullStr | Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering |
title_full_unstemmed | Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering |
title_short | Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering |
title_sort | advances of stimulus-responsive hydrogels for bone defects repair in tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222548/ https://www.ncbi.nlm.nih.gov/pubmed/35735733 http://dx.doi.org/10.3390/gels8060389 |
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