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Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering

Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and...

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Detalles Bibliográficos
Autores principales: Chang, Shuai, Wang, Shaobo, Liu, Zhongjun, Wang, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222548/
https://www.ncbi.nlm.nih.gov/pubmed/35735733
http://dx.doi.org/10.3390/gels8060389
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author Chang, Shuai
Wang, Shaobo
Liu, Zhongjun
Wang, Xing
author_facet Chang, Shuai
Wang, Shaobo
Liu, Zhongjun
Wang, Xing
author_sort Chang, Shuai
collection PubMed
description Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and degradability. Stimulus-responsive hydrogels, as a new type of smart biomaterial, have more advantages in sensing external physical (light, temperature, pressure, electric field, magnetic field, etc.), chemical (pH, redox reaction, ions, etc.), biochemical (glucose, enzymes, etc.) and other different stimuli. They can respond to stimuli such as the characteristics of the 3D shape and solid–liquid phase state, and exhibit special properties (injection ability, self-repair, shape memory, etc.), thus becoming an ideal material to provide cell adhesion, proliferation, and differentiation, and achieve precise bone defect repair. This review is focused on the classification, design concepts, and research progress of stimulus-responsive hydrogels based on different types of external environmental stimuli, aiming at introducing new ideas and methods for repairing complex bone defects.
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spelling pubmed-92225482022-06-24 Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering Chang, Shuai Wang, Shaobo Liu, Zhongjun Wang, Xing Gels Review Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and degradability. Stimulus-responsive hydrogels, as a new type of smart biomaterial, have more advantages in sensing external physical (light, temperature, pressure, electric field, magnetic field, etc.), chemical (pH, redox reaction, ions, etc.), biochemical (glucose, enzymes, etc.) and other different stimuli. They can respond to stimuli such as the characteristics of the 3D shape and solid–liquid phase state, and exhibit special properties (injection ability, self-repair, shape memory, etc.), thus becoming an ideal material to provide cell adhesion, proliferation, and differentiation, and achieve precise bone defect repair. This review is focused on the classification, design concepts, and research progress of stimulus-responsive hydrogels based on different types of external environmental stimuli, aiming at introducing new ideas and methods for repairing complex bone defects. MDPI 2022-06-20 /pmc/articles/PMC9222548/ /pubmed/35735733 http://dx.doi.org/10.3390/gels8060389 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chang, Shuai
Wang, Shaobo
Liu, Zhongjun
Wang, Xing
Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
title Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
title_full Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
title_fullStr Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
title_full_unstemmed Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
title_short Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering
title_sort advances of stimulus-responsive hydrogels for bone defects repair in tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222548/
https://www.ncbi.nlm.nih.gov/pubmed/35735733
http://dx.doi.org/10.3390/gels8060389
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