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Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing?
Aspergillosis is a disease caused by Aspergillus, and invasive pulmonary aspergillosis (IPA) is the most common invasive fungal infection leading to death in severely immuno-compromised patients. The literature reports Aspergillus co-infections in patients with COVID-19 (CAPA). Diagnosing CAPA clini...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222563/ https://www.ncbi.nlm.nih.gov/pubmed/35742328 http://dx.doi.org/10.3390/ijerph19127079 |
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author | Caggiano, Giuseppina Apollonio, Francesca Consiglio, Mila Gasparre, Valentina Trerotoli, Paolo Diella, Giusy Lopuzzo, Marco Triggiano, Francesco Stolfa, Stefania Mosca, Adriana Montagna, Maria Teresa |
author_facet | Caggiano, Giuseppina Apollonio, Francesca Consiglio, Mila Gasparre, Valentina Trerotoli, Paolo Diella, Giusy Lopuzzo, Marco Triggiano, Francesco Stolfa, Stefania Mosca, Adriana Montagna, Maria Teresa |
author_sort | Caggiano, Giuseppina |
collection | PubMed |
description | Aspergillosis is a disease caused by Aspergillus, and invasive pulmonary aspergillosis (IPA) is the most common invasive fungal infection leading to death in severely immuno-compromised patients. The literature reports Aspergillus co-infections in patients with COVID-19 (CAPA). Diagnosing CAPA clinically is complex since the symptoms are non-specific, and performing a bronchoscopy is difficult. Generally, the microbiological diagnosis of aspergillosis is based on cultural methods and on searching for the circulating antigens galactomannan and 1,3-β-D-glucan in the bronchoalveolar lavage fluid (bGM) or serum (sGM). In this study, to verify whether the COVID-19 period has stimulated clinicians to pay greater attention to IPA in patients with respiratory tract infections, we evaluated the number of requests for GM-Ag research and the number of positive tests found during the pre-COVID-19 and COVID-19 periods. Our data show a significant upward trend in GM-Ag requests and positivity from the pre-COVID to COVID period, which is attributable in particular to the increase in IPA risk factors as a complication of COVID-19. In the COVID period, parallel to the increase in requests, the number of positive tests for GM-Ag also increased, going from 2.5% in the first period of 2020 to 12.3% in the first period of 2021. |
format | Online Article Text |
id | pubmed-9222563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92225632022-06-24 Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? Caggiano, Giuseppina Apollonio, Francesca Consiglio, Mila Gasparre, Valentina Trerotoli, Paolo Diella, Giusy Lopuzzo, Marco Triggiano, Francesco Stolfa, Stefania Mosca, Adriana Montagna, Maria Teresa Int J Environ Res Public Health Article Aspergillosis is a disease caused by Aspergillus, and invasive pulmonary aspergillosis (IPA) is the most common invasive fungal infection leading to death in severely immuno-compromised patients. The literature reports Aspergillus co-infections in patients with COVID-19 (CAPA). Diagnosing CAPA clinically is complex since the symptoms are non-specific, and performing a bronchoscopy is difficult. Generally, the microbiological diagnosis of aspergillosis is based on cultural methods and on searching for the circulating antigens galactomannan and 1,3-β-D-glucan in the bronchoalveolar lavage fluid (bGM) or serum (sGM). In this study, to verify whether the COVID-19 period has stimulated clinicians to pay greater attention to IPA in patients with respiratory tract infections, we evaluated the number of requests for GM-Ag research and the number of positive tests found during the pre-COVID-19 and COVID-19 periods. Our data show a significant upward trend in GM-Ag requests and positivity from the pre-COVID to COVID period, which is attributable in particular to the increase in IPA risk factors as a complication of COVID-19. In the COVID period, parallel to the increase in requests, the number of positive tests for GM-Ag also increased, going from 2.5% in the first period of 2020 to 12.3% in the first period of 2021. MDPI 2022-06-09 /pmc/articles/PMC9222563/ /pubmed/35742328 http://dx.doi.org/10.3390/ijerph19127079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Caggiano, Giuseppina Apollonio, Francesca Consiglio, Mila Gasparre, Valentina Trerotoli, Paolo Diella, Giusy Lopuzzo, Marco Triggiano, Francesco Stolfa, Stefania Mosca, Adriana Montagna, Maria Teresa Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? |
title | Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? |
title_full | Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? |
title_fullStr | Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? |
title_full_unstemmed | Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? |
title_short | Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing? |
title_sort | tendency in pulmonary aspergillosis investigation during the covid-19 era: what is changing? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222563/ https://www.ncbi.nlm.nih.gov/pubmed/35742328 http://dx.doi.org/10.3390/ijerph19127079 |
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