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A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection

Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months aft...

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Autores principales: Leonso, Ana-Alicia, Brown, Kyle, Prol, Raquel, Rawat, Saumya, Khunger, Arjun, Bromberg, Romina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222568/
https://www.ncbi.nlm.nih.gov/pubmed/35735758
http://dx.doi.org/10.3390/idr14030048
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author Leonso, Ana-Alicia
Brown, Kyle
Prol, Raquel
Rawat, Saumya
Khunger, Arjun
Bromberg, Romina
author_facet Leonso, Ana-Alicia
Brown, Kyle
Prol, Raquel
Rawat, Saumya
Khunger, Arjun
Bromberg, Romina
author_sort Leonso, Ana-Alicia
collection PubMed
description Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months after a successful inpatient treatment of COVID-19. A 74-year-old female from the Philippines presented with a new left mid-lung infiltrate with worsening shortness of breath and lethargy for one week prior to admission. The clinical course of the patient deteriorated despite broad-spectrum antibiotics, diuretics, and high-dose steroid therapy requiring intubation and mechanical ventilation. Her sputum culture yielded the microbiological diagnosis of TB. Anti-tubercular medications were started and the patient had a favorable clinical outcome. Our case demonstrates that immunosuppression secondary to COVID-19 and its treatments may promote the development of an active TB infection from a latent infection. It is important to be aware of this potential increase in risk during and after a COVID-19 treatment. This is especially important in high-risk populations to ensure an early diagnosis and prompt management as well as to reduce transmission.
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spelling pubmed-92225682022-06-24 A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection Leonso, Ana-Alicia Brown, Kyle Prol, Raquel Rawat, Saumya Khunger, Arjun Bromberg, Romina Infect Dis Rep Case Report Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months after a successful inpatient treatment of COVID-19. A 74-year-old female from the Philippines presented with a new left mid-lung infiltrate with worsening shortness of breath and lethargy for one week prior to admission. The clinical course of the patient deteriorated despite broad-spectrum antibiotics, diuretics, and high-dose steroid therapy requiring intubation and mechanical ventilation. Her sputum culture yielded the microbiological diagnosis of TB. Anti-tubercular medications were started and the patient had a favorable clinical outcome. Our case demonstrates that immunosuppression secondary to COVID-19 and its treatments may promote the development of an active TB infection from a latent infection. It is important to be aware of this potential increase in risk during and after a COVID-19 treatment. This is especially important in high-risk populations to ensure an early diagnosis and prompt management as well as to reduce transmission. MDPI 2022-06-12 /pmc/articles/PMC9222568/ /pubmed/35735758 http://dx.doi.org/10.3390/idr14030048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Leonso, Ana-Alicia
Brown, Kyle
Prol, Raquel
Rawat, Saumya
Khunger, Arjun
Bromberg, Romina
A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
title A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
title_full A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
title_fullStr A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
title_full_unstemmed A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
title_short A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
title_sort rare case of latent tuberculosis reactivation secondary to a covid-19 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222568/
https://www.ncbi.nlm.nih.gov/pubmed/35735758
http://dx.doi.org/10.3390/idr14030048
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