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The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study

Athletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modul...

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Autores principales: Pasqualetti, Massimo, Onori, Maria Elisabetta, Canu, Giulia, Moretti, Giacomo, Minucci, Angelo, Baroni, Silvia, Mordente, Alvaro, Urbani, Andrea, Galvani, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222624/
https://www.ncbi.nlm.nih.gov/pubmed/35741731
http://dx.doi.org/10.3390/genes13060969
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author Pasqualetti, Massimo
Onori, Maria Elisabetta
Canu, Giulia
Moretti, Giacomo
Minucci, Angelo
Baroni, Silvia
Mordente, Alvaro
Urbani, Andrea
Galvani, Christel
author_facet Pasqualetti, Massimo
Onori, Maria Elisabetta
Canu, Giulia
Moretti, Giacomo
Minucci, Angelo
Baroni, Silvia
Mordente, Alvaro
Urbani, Andrea
Galvani, Christel
author_sort Pasqualetti, Massimo
collection PubMed
description Athletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modulation of genetic influence on rugby-specific physical performance. Twenty-seven elite rugby union players were involved in the study during the in-season phase. Molecular genotyping was performed for: angiotensin-converting enzyme (ACE rs4646994), alfa-actinin-3 (ACTN3 rs1815739) and monocarboxylate transporter 1 (MCT1 rs1049434) and their variants. Lean mass index (from skinfolds), lower-limb explosive power (countermovement jump), agility (505), speed (20 m), maximal aerobic power (Yo-yo intermittent recovery test level 1) and repeated sprint ability (12 × 20 m) were evaluated. In our rugby union players ACE and ACTN3 variants did not show any influence on athletic performance. MCT1 analysis showed that TT-variant players had the highest peak vertical power (p = 0.037) while the ones with the AA genotype were the fastest in both agility and sprint tests (p = 0.006 and p = 0.012, respectively). Considering the T-dominant model, the AA genotype remains the fastest in both tests (agility: p = 0.013, speed: p = 0.017). Only the MCT1 rs1049434 A allele seems to be advantageous for elite rugby union players, particularly when power and speed are required.
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spelling pubmed-92226242022-06-24 The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study Pasqualetti, Massimo Onori, Maria Elisabetta Canu, Giulia Moretti, Giacomo Minucci, Angelo Baroni, Silvia Mordente, Alvaro Urbani, Andrea Galvani, Christel Genes (Basel) Article Athletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modulation of genetic influence on rugby-specific physical performance. Twenty-seven elite rugby union players were involved in the study during the in-season phase. Molecular genotyping was performed for: angiotensin-converting enzyme (ACE rs4646994), alfa-actinin-3 (ACTN3 rs1815739) and monocarboxylate transporter 1 (MCT1 rs1049434) and their variants. Lean mass index (from skinfolds), lower-limb explosive power (countermovement jump), agility (505), speed (20 m), maximal aerobic power (Yo-yo intermittent recovery test level 1) and repeated sprint ability (12 × 20 m) were evaluated. In our rugby union players ACE and ACTN3 variants did not show any influence on athletic performance. MCT1 analysis showed that TT-variant players had the highest peak vertical power (p = 0.037) while the ones with the AA genotype were the fastest in both agility and sprint tests (p = 0.006 and p = 0.012, respectively). Considering the T-dominant model, the AA genotype remains the fastest in both tests (agility: p = 0.013, speed: p = 0.017). Only the MCT1 rs1049434 A allele seems to be advantageous for elite rugby union players, particularly when power and speed are required. MDPI 2022-05-28 /pmc/articles/PMC9222624/ /pubmed/35741731 http://dx.doi.org/10.3390/genes13060969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pasqualetti, Massimo
Onori, Maria Elisabetta
Canu, Giulia
Moretti, Giacomo
Minucci, Angelo
Baroni, Silvia
Mordente, Alvaro
Urbani, Andrea
Galvani, Christel
The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
title The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
title_full The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
title_fullStr The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
title_full_unstemmed The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
title_short The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
title_sort relationship between ace, actn3 and mct1 genetic polymorphisms and athletic performance in elite rugby union players: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222624/
https://www.ncbi.nlm.nih.gov/pubmed/35741731
http://dx.doi.org/10.3390/genes13060969
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