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Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A

Exposure to titanium dioxide nanoparticles (TiO(2) NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO(2) NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks....

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Autores principales: Yang, Chen, Tan, Youlan, Li, Fengzhu, Wang, Hongbin, Lin, Ying, Lu, Fuping, Zhao, Huabing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222895/
https://www.ncbi.nlm.nih.gov/pubmed/35741895
http://dx.doi.org/10.3390/foods11121696
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author Yang, Chen
Tan, Youlan
Li, Fengzhu
Wang, Hongbin
Lin, Ying
Lu, Fuping
Zhao, Huabing
author_facet Yang, Chen
Tan, Youlan
Li, Fengzhu
Wang, Hongbin
Lin, Ying
Lu, Fuping
Zhao, Huabing
author_sort Yang, Chen
collection PubMed
description Exposure to titanium dioxide nanoparticles (TiO(2) NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO(2) NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO(2) NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO(2) NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO(2) NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO(2) NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota.
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spelling pubmed-92228952022-06-24 Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A Yang, Chen Tan, Youlan Li, Fengzhu Wang, Hongbin Lin, Ying Lu, Fuping Zhao, Huabing Foods Article Exposure to titanium dioxide nanoparticles (TiO(2) NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO(2) NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO(2) NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO(2) NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO(2) NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO(2) NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota. MDPI 2022-06-09 /pmc/articles/PMC9222895/ /pubmed/35741895 http://dx.doi.org/10.3390/foods11121696 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Chen
Tan, Youlan
Li, Fengzhu
Wang, Hongbin
Lin, Ying
Lu, Fuping
Zhao, Huabing
Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A
title Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A
title_full Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A
title_fullStr Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A
title_full_unstemmed Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A
title_short Intestinal Microecology of Mice Exposed to TiO(2) Nanoparticles and Bisphenol A
title_sort intestinal microecology of mice exposed to tio(2) nanoparticles and bisphenol a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222895/
https://www.ncbi.nlm.nih.gov/pubmed/35741895
http://dx.doi.org/10.3390/foods11121696
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